Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aggressors Need Dopamine, and Victims Require Serotnin

07.12.2004


The Novosibirsk researchers have managed to establish connection between mice’s aggressive behavior, biochemical modifications in their brain and the genes that cause those modifications.



Aggressive behavior is to a large extent genetically determined. The evidence of that are experiments with laboratory animals, including their successful selection into high- and low-aggressive lines. However, the “aggression gene” as such will hardly be ever found. Nevertheless, the researchers have managed to find the genes that are connected with aggressive behavior. Thus, researchers of the Institute of Cytology and Genetics (Siberian Branch, Russian Academy of Sciences) and Novosibirsk Institute of Bioorganic Chemistry (Siberian Branch, Russian Academy of Sciences, Novosibirsk) have analyzed biochemical modifications taking place in the brain of mice after aggressive collisions and have found the genes responsible for that.

Male mice scuffled with each other every day: the stronger ones used to attack and assault, the weaker ones – used to run away or posed as the subordinated. As a result of recurring fights some males won victories all the time and gained “experience of victors” - they became even more aggressive. Others got into position of “ chronical victims” who are in the state of constant stress. Both types changed their behavior. However, as the researchers have demonstrated, biochemistry of brain changed as well. The researchers measured the content of basic neuromediators – i.e. the substances that transmit a signal from one nerve cell to another – in the brain of winner mice and victim mice, and the products of their chemical transformations. The researchers were most interested in the dopamine and serotonin neuromediators. It has turned out that the recurring aggression experience of the “winners” leads to activation of the neurons system that uses dopamine (i.e., the dopaminergic system). However, the recurring experience of defeats with the “victims” causes weakening the dopaminergic system work, but in return, it activates the system of neurons that use serotonin – the serotonergic system. Apparently, these two systems work in antiphase.


At the next phase of investigation, the researchers faced the task of passing “from behavior to the gene”. Proceeding from biochemical results, the researchers worked with the genes that are connected with the dopaminergic and serotonergic systems of the brain. The difficulty is that neuromediators are not proteins. A gene contains information about protein synthesis. However, there exist multiple proteins that ensure the work of neuromediators, for example, enzymes participating in their transformations, and protein receptors on the membrane. The genes of these proteins constituted the subject of investigation. Namely, COMP gene that encodes enzyme of the dopamine and noradrenaline metabolism, TG gene that limits the rate of synthesis of these neuromediators, DAT gene that ceases the dopamine action on the cellular membrane, SERT gene that provides for transfer of serotonin and MAOA that causes its inactivation. The work of all these genes changed to the opposite with the winners and victims. The researchers made sure that formation of aggressive or submissive (subordinated) type of behavior causes realignment of work of several genes which leads to changes in activity of the neuromediator systems. Thus, the researchers have managed to find experimental approach that allows to establish connection between behavior to the gene. At least in terms of aggression. The research has been funded through grants from the Russian Foundation for Basic Research and INTAS.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Opioids: no effect without side effect
21.01.2019 | Universitätsklinikum Jena

nachricht The cytoskeleton of neurons has been found to be involved in Alzheimer's disease
18.01.2019 | University of the Basque Country

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ten-year anniversary of the Neumayer Station III

The scientific and political community alike stress the importance of German Antarctic research

Joint Press Release from the BMBF and AWI

The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...

Im Focus: Ultra ultrasound to transform new tech

World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles

The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.

Im Focus: Flying Optical Cats for Quantum Communication

Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.

In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...

Im Focus: Nanocellulose for novel implants: Ears from the 3D-printer

Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.

It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:

Im Focus: Elucidating the Atomic Mechanism of Superlubricity

The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.

One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Our digital society in 2040

16.01.2019 | Event News

11th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Aachen, 3-4 April 2019

14.01.2019 | Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

 
Latest News

Scientists discover new 'architecture' in corn

21.01.2019 | Life Sciences

Broadband achromatic metalens focuses light regardless of polarization

21.01.2019 | Physics and Astronomy

Nuclear actin filaments determine T helper cell function

21.01.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>