Patients given a class of anti-inflammatory drugs before and after minimally invasive laparoscopic surgery experienced less pain with fewer postoperative complications and an earlier return to normal activities, according to Duke University Medical Center researchers.
CREDIT: Duke University Medical Center
The class of drugs in question, known as cyclooxygenase (COX)-2 inhibitors, block a key enzyme in the cascade of immune system events leading to inflammation. Unlike other non-steroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors do not have any significant effect on blood platelet or gastrointestinal function.
The results of the multi-center Phase III clinical trial, which were published in the June 2004 issue of the journal Anesthesia & Analgesia, demonstrated that the use of COX-2 inhibitors lessened the amount of opiates needed to control pain, as well as reduced the incidence of postoperative nausea and vomiting (PONV). By controlling these events, the use of COX-2 inhibitors allowed patients to return home sooner and more comfortably, the researchers said.
Richard Merritt | dukemed news
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