Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An alternative to bone-marrow donation

29.03.2004


Researchers have developed a method to reconstitute bone marrow and blood cells from embryonic stem (ES) cells. As reported in The Journal of Experimental Medicine, this method was effective even in genetically mismatched mice. If the same is true in humans, this would remove the need to find genetically matched human bone-marrow donors for patients with leukemia, immune deficiencies and autoimmune diseases.



ES cells are cells derived from embryos that have the potential to grow into many different cell types. Richard Burt and colleagues identified the most effective mix of growth factors to induce mouse ES cell lines to develop into bone-marrow and blood precursor cells in culture. They also devised a method to select the best cells from these cultures. Injection of the selected cells into the bone marrow of mice that had been depleted of their own bone-marrow cells resulted in restoration of blood cells, including cells of the immune system, which are normally produced in the bone marrow.

Despite the genetic mismatch between donor and recipient, the injected cells were not rejected. This is consistent with previous evidence that ES cells are somehow less susceptible than adult cells to being identified as foreign by the immune system. The basis of this difference is not understood.


There was also no evidence that the immune cells derived from ES cells were attacking the recipient. The equivalent process after bone marrow transplantation is an often fatal complication known as graft-versus-host disease. The immune response to foreign antigens was, however, normal, indicating that recipients would be able to fight off infection efficiently.

Although the use of ES cell lines is controversial, it has many potential advantages over the use of cells from donor bone marrow or blood. The latter cells are highly variable, cannot be cultured in the lab and often cause graft-versus-host disease. Human ES cell lines can be cultured indefinitely, providing a renewable and well-defined source that is free from bacterial contamination.


Contact: Dr Richard Burt, Northwestern University, Chicago, 312-908-0059, rburt@nwu.edu

Lynette Henry | EurekAlert!
Further information:
http://www.rupress.org/

More articles from Health and Medicine:

nachricht Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>