Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New clinical study uncovers mechanism by which chromium picolinate may enhance insulin sensitivity

29.08.2003


Effective and safe complementary nutrition therapy



The results of a new double-blind randomized placebo controlled human trial of people with type 2 diabetes revealed a potential mechanism that may explain the ability of chromium picolinate to improve insulin resistance in human skeletal muscle – the primary site for glucose metabolism. These data suggest that when chromium picolinate is added to the diet, insulin sensitivity improves for people with diabetes, a chronic disease that affects 194 million people worldwide. The findings were presented by Dr. William T. Cefalu from the University of Vermont College of Medicine, USA at the 18th International Diabetes Federation Congress.

Research suggests that the potential in vivo mechanism of chromium picolinate on insulin action in human skeletal muscle may occur by increasing the activation of Akt phosphorylation -- an intracellular insulin dependent protein that facilitates the uptake of glucose into cells.


"This study demonstrates that those individuals with type 2 diabetes who supplemented their diet with chromium picolinate had an enhanced activity of the protein compared to those who were on placebo," stated Dr. Cefalu. "As this intracellular pathway is implicated in contributing to insulin resistance, this represents a possible mechanism to explain chromium picolinate’s beneficial effect on insulin sensitivity as observed in several clinical studies."

The clinical trial
The double-blind, placebo controlled trial, included two cohorts of subjects with type 2 diabetes who were treated with either sulfonylureas (a class of diabetic drugs that increase insulin secretion), or a diet program. Both groups were randomized to receive either chromium picolinate (1000 mcg) daily or placebo. The most accurate measure of insulin sensitivity, hyperinsulinemic, euglycemic clamp studies, were used to assess the efficacy of glucose uptake on all subjects prior to randomization and at the end of the study. Of the 16 subjects, those randomized to chromium picolinate had a mean increase in insulin sensitivity of 8.9%, while the placebo group had a mean decrease of 3.6%. In addition, insulin-stimulated Akt activation was significantly increased at the end of the study compared to those subjects on placebo. No adverse events were reported.

A Cost Effective Nutrition Therapy
The World Health Organization (WHO) estimates that four to five percent of health budgets are spent on diabetes-related illnesses and that people with diabetes incur medical costs two to five times higher than people without diabetes.

Chromium is an essential mineral that is a co-factor of insulin. "By applying rigorous science, we hope to show it’s potential to improve the quality of patient care for people with diabetes and reduce cost of therapy," said James Komorowski, MS, Vice President of Technical Services and Scientific Affairs, Nutrition 21, Inc., which supplied Chromax? chromium picolinate for the study. Chromax chromium picolinate is the most clinically tested brand of chromium with proven efficacy for support of glucose metabolism. "This new research further supports the large body of scientific evidence showing chromium picolinate is a safe and effective addition to the diet for people with type 2 diabetes seeking optimal control of their blood sugar levels."


Nutrition 21 provided an unrestricted research grant and Chromax® chromium picolinate for the trial. Nutrition 21 is a leading developer and provider of nutritional products, whose health benefits are substantiated by clinical research. The Company markets Chromax chromium picolinate, the leading brand of chromium, and holds 35 patents for nutrition products, 22 for chromium compounds and their uses. More information is available at www.nutrition21.com. More information about Chromax is available at www.chromax.com.

Stacey Antine | EurekAlert!
Further information:
http://www.chromax.com
http://www.nutrition21.com/

More articles from Health and Medicine:

nachricht Deep stimulation improves cognitive control by augmenting brain rhythms
04.04.2019 | Picower Institute at MIT

nachricht Black nanoparticles slow the growth of tumors
04.04.2019 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>