Researchers at Ohio State found that endostatin has a dual effect on head and neck cancer cells – the compound prevented the cells from developing new blood vessels and also hindered the mechanism cancer cells use to migrate throughout the body and invade other tissues.
Head and neck cancers originate on the epithelium – the layer of tissue covering the outermost surfaces of the body, including the skin and mucus membranes. Kaposi’s sarcoma tumors arise from the endothelium, the cells that line blood vessels.
“The vast majority of endostatin studies have concentrated on endostatin’s effects against endothelial cells, and haven’t focused on the drug’s anti-tumorigenic possibilities,” said Susan Mallery, the study’s lead author and a professor in the Ohio State College of Dentistry’s department of oral and maxillofacial surgery and pathology.
Holly Wagner | Ohio State University
Researchers image atomic structure of important immune regulator
11.12.2018 | Brigham and Women's Hospital
Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
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New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
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