A research study under way at Northwestern Memorial Hospital is trying to find out if the popular anti-inflammatory drug Celebrex might do more than ease arthritis pain. Researchers at Northwestern Memorial are enrolling patients with early stage head and neck cancers or non-small cell lung cancers in a research study to see if Celebrex reduces the return of old tumors or the chance of getting a new cancer when taken after surgery or radiation treatments.
The double-blind, randomized study will enroll about 120 patients at Northwestern Memorial, the primary teaching hospital of Northwestern Universitys Feinberg School of Medicine. Celebrex belongs to a class of drugs called COX-2 inhibitors that block the production of an enzyme called cyclooxygenese–2 or simply COX-2. COX-2 triggers pain and inflammation in arthritis sufferers and may also fuel the growth of cancer.
"COX-2 inhibitors have emerged in recent years as a promising anticancer therapy. Many cancers have high levels of COX-2," explains Athanassios Argiris, M.D., an oncologist at Northwestern Memorial Hospital. Dr. Argiris, who coordinates the clinical research in lung as well as head and neck cancer at the Robert H. Lurie Comprehensive Cancer Center, is the principal investigator of the research study, which is also expected to open in other major institutions in the U.S. in the coming months. COX-2 may promote the growth of new blood vessels that nourish the cancer tumors. "Taking Celebrex may starve the tumor of nutrients in a process called anti-angiogenesis," he says. "It also appears to promote self-destruction of cancer cells."
Amanda Widtfeldt | EurekAlert!
Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine
Breakthrough in understanding how deadly pneumococcus avoids immune defenses
13.11.2018 | University of Liverpool
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
13.11.2018 | Life Sciences
13.11.2018 | Life Sciences
13.11.2018 | Awards Funding