Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Personalised doses of insulin

05.02.2003


Diabetes is a widespread illness affecting 5 per cent of the population. In diabetics the metabolism produces an excess of glucose in the blood and, as a result, a number of sufferers need doses of insulin which allows them to regulate their glucose levels.



Currently, the method of administering insulin to diabetic patients making use of emergency services for insulin dosage depends on the experience of the qualified personnel. That is, the same patient can receive different insulin doses, and in different ways, according to the doctor attending her or him.

In order to improve this system of administration, Doctor Tomás Rubio proposed in his doctoral thesis the development of a mathematical model which would facilitate predicting the exact amount of insulin needed by a patient at any time. The thesis showed that both the absorption constant (the time taken for the insulin to enter the blood and become effective) as well as the elimination constant (the time taken for the insulin to disappear), is different for each patient. Moreover, for any one patient this absorption constant varies with time.


Given this, Doctor Tomás Rubio proposed using a technique based in blood extractions. He concluded that, by taking samples at two different times, the level of glycemia can be measured and the constants of absorption and elimination can be calculated. Knowing these constants, the exact amount of insulin needed by the patient can be calculated. Nevertheless, if the patient suffers another decompensation crisis, it will be necessary to recalculate these constants.

Apart from its use in emergency services, this model has applications for self-medication by the patient at home. For example, it can be used with the insulin perfusion pumps currently used to apply a quantity of insulin, depending on the glucose level. It can also be used with patients undergoing surgery in order to know how much insulin has to be administered during the operation and to control the amount of glucose administered via serum.

Two types of patients

Two types of patients are distinguished in this study. The first corresponds to insulin-dependant diabetic patients, normally young people, who require insulin for their treatment and whose acute condition is usually diabetic ketoacidosis. The second type corresponds to patients who have very high levels of glycemia, usually older and overweight people, who are normally regulated through orally administered antidiabetic medication, although many of these also end up needing insulin. These patients show acute conditions of hyperosmolar coma and symptomatic hyperglycemia.

The research was carried out on patients with the different acute conditions: diabetic ketoacidosis, hyperosmolar coma and symptomatic hyperglycemia. From the analysis of the results it was concluded that, for the construction of the mathematical model, the measuring of glycemia and insulin were necessary

Contact :
Iñaki Casado Redin
Nafarroako Unibertsitate Publikoa
inaki.casado@unavarra.es
(+34) 948 16 97 82

Iñaki Casado Redin | BasqueResearch
Further information:
http://www.unavarra.es

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>