An experimental drug designed to cut off a tumors blood supply showed promising results in patients with advanced colorectal cancer when paired with standard chemotherapy, according to a UCLA Jonsson Cancer Center study published in the Jan. 1 issue of the Journal of Clinical Oncology.
The results of this and subsequent studies of the experimental drug Avastin could change the way oncologists treat patients with this devastating form of cancer, said Dr. Fairooz Kabbinavar, a Jonsson Cancer Center researcher and first author of the peer-reviewed journal article. The combination of Avastin and chemotherapy proved superior to chemotherapy alone in treating advanced colorectal cancer, Kabbinavar said.
"This is a first-ever randomized trial of a potent anti-angiogenic agent, comparing chemotherapy alone to chemotherapy and Avastin in patients with advanced colorectal cancer," said Kabbinavar, an associate professor of hematology/oncology at UCLA who has studied this drug in the lab and in patients for the last decade. "This study could give us a less toxic and a more effective weapon in our growing arsenal of cancer therapies."
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