Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Developments in Angiogenic Therapy Emerging from Oxford

26.08.2002


Angiogenesis, the growth of new blood vessels, is important in the healthy body for healing wounds and, in females, for the monthly reproductive cycle and during pregnancy. It is controlled in the body through the use of the body’s own angiogenesis inhibitors and stimulators. In certain diseases the body is unable to control blood vessel growth. In diseases such as cancer, diabetic blindness and psoriasis, excessive angiogenesis is occurring; and in diseases such as coronary artery disease and stroke insufficient angiogenesis is the problem.



A novel anti-angiogenic agent

Researchers in the Cancer Research UK Molecular Oncology Laboratory at Oxford University have now identified a new inhibitor of endothelial cell proliferation with possible applications in the treatment of those disorders listed above which are characterised by excessive angiogenesis.


For example, solid cancer tumours are often characterised as being angiogenic, i.e. having an increased blood supply. One promising new treatment for solid tumours proposes to cut off the tumour’s blood supply with subsequent tumour shrinkage. Endothelial cells that line normal blood vessels are usually quiescent while those within tumour blood vessels are proliferating. Anti-angiogenic agents that can selectively inhibit proliferating endothelial cells or cytotoxic agents that can be delivered to the tumour vasculature have huge potential for the treatment of solid tumours.

Oxford, Imperial College and Cancer Research UK scientists, led by Professor Adrian Harris, have now identified a new agent for solving this problem. An anti-angiogenic peptide has been isolated and characterised. This peptide is a new member of the family of anti-angiogenic molecules that includes angiostatin which have for some years been of great interest to the pharmaceutical community. It has been shown in experiments to be an effective inhibitor of endothelial cell proliferation.

A new lead in the fight against Coronary Artery Disease

Alternatively, it has been found that the antibody to the peptide is effective in promoting the proliferation of endothelial cells and is thus a potential angiogenic agent for the treatment of disorders such as coronary artery disease. Angiogenic therapy can alleviate coronary artery disease by stimulating new vessel growth and returning blood flow to the heart, through the delivery of angiogenic proteins or their genes to this organ. Endothelial cells that line blood vessels are the initial targets for promoting new vessel growth. Therefore new biological agents that can stimulate endothelial cell growth, such as this antibody, are important candidates for angiogenic therapy.

Isis Innovation, Oxford University’s technology transfer company, holds the patent application for this project and is actively seeking partners for the licensing and commercial development of these technologies.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com/licensing/779.html

More articles from Health and Medicine:

nachricht Finding new clues to brain cancer treatment
21.02.2020 | Case Western Reserve University

nachricht UIC researchers find unique organ-specific signature profiles for blood vessel cells
18.02.2020 | University of Illinois at Chicago

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Active droplets

21.02.2020 | Medical Engineering

Finding new clues to brain cancer treatment

21.02.2020 | Health and Medicine

Beyond the brim, Sombrero Galaxy's halo suggests turbulent past

21.02.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>