Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Potential blood test for chronic sinusitis identified

15.04.2008
A protein profile has been identified in the blood of chronic sinusitis sufferers that may enable physicians to objectively diagnosis and treat the disease, researchers say.

They used a sophisticated research tool that rapidly assesses expression of large numbers of proteins and found among 96 chronic sinusitis patients a profile missing in 38 healthy controls.

“We can diagnose this disease with a totally objective test that does not depend on symptoms or observations,” says Dr. Stilianos E. Kountakis, vice chair of the Department of Otolaryngology-Head and Neck Surgery in the Medical College of Georgia School of Medicine. He is corresponding author on the study published in the March/April issue of American Journal of Rhinology.

Diagnosing this chronically irritating disease, characterized by dripping noses, sinus pressure, congestion and difficulty breathing, currently is rather subjective. Patients talk about symptoms and doctors look at their sinuses with an endoscope and probably a computerized tomography scan. “… (O)verall management of (chronic sinusitis) is still hampered by the lack of quantifiable, molecular and genetic markers to aid in screening,” researchers write.

To be classified chronic, the misery has to continue for at least 12 weeks. Causes include bacterial infections, respiratory inflammation, sinus polyps and mucosal disease. Some causes, such as polyps and asthma, have a genetic predisposition. “You may have a bacterial infections, allergies, mechanical problems,” Dr. Kountakis says. “There are numerous genes that control respiratory function. Any of these things can go wrong to predispose the patient to develop chronic sinusitis.”

Treating it isn’t much more straightforward. Surgery can help correct anatomical causes such as deviated septums or polyps. However, there are no FDA-aproved drugs specifically to treat chronic sinusitis. Instead, physicians use drugs that treat symptoms: steroid sprays for inflammation, mucus thinners, saline irrigation, etc. “It’s difficult to show drugs are effective because it’s difficult to group patients together and measure their disease,” says Dr. Kountakis.

He hopes further studies will enable both, revealing signature protein profiles for different types of chronic sinusitis as well as the degree of disease. “The bottom line is we want to group patients according to their disease rather than just the general term chronic sinusitis,” Dr. Kountakis says. “If we can find a way to classify patients, group them together based on the specific disease they have, maybe we can get better outcomes and treat patients with better efficiency.”

These objective measures should allow monitoring the effectiveness of current therapies and objectively reviewing new ones, he says.

In fact, even getting a handle on disease incidence is tough. The National Health Interview Survey, based on self-reports, says 14 to 16 percent of people in the United States have chronic sinusitis. A population-based study of the Olmsted County, Minnesota published in 2004 in Archives of Otolaryngology-Head & Neck Surgery put the incidence at 2 percent.

For this study, researchers analyzed protein expression in the blood using surface enhanced laser desorption ionization time-of-flight mass spectroscopy or SELDI-TOF-MS. The test is about 88 percent accurate.

Co-authors include Drs. Adam M. Becker, Subinoy Das, Zhongsheng Xia; Zhongmin Liu and Bao-Ling Adam.

Toni Baker | EurekAlert!
Further information:
http://www.mcg.edu

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>