Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity is a poor gauge for detecting high cholesterol levels in children

04.08.2009
U-M study finds that national cholesterol testing guidelines for children may need to be revised

With the epidemic of childhood obesity in the United States, there is concern that overweight and obese children need to be screened for chronic medical conditions, including high cholesterol levels.

However, body fat is not an effective indicator of high cholesterol in children, according to new University of Michigan research.

Those are the findings of a U-M study led by U-M pediatricians Joyce Lee, M.D., MPH, and Matthew Davis, M.D., MAPP, which will appear in the August 3 edition of the Archives of Pediatric and Adolescent Medicine.

"We found, actually, that using body mass index to find kids with high cholesterol does not work well. There were many overweight and obese kids who had normal cholesterol, and there were a fair number of healthy-weight kids who had high cholesterol," says Lee, a member of the Child Health Evaluation and Research (CHEAR) Unit in the U-M Division of General Pediatrics, and assistant professor in the Department of Pediatrics and Communicable Diseases at the U-M Medical School.

The study was conducted after the American Academy of Pediatrics revised its cholesterol screening guidelines in July 2008, advocating a cholesterol check for kids who have increased risk of heart disease. For the most part, that means all children who are overweight or obese, which is about 30% of kids in the U.S.

"Our results indicate that the AAP guidelines for cholesterol screening in kids may need to be revised," says Lee. "Otherwise, we may be missing high cholesterol in some kids and unnecessarily testing others."

The authors performed the study with national data from thousands of children to see whether 'body mass index' (BMI), a measure of body fat based on height and weight, can be used as a reliable way to find kids with high cholesterol levels. They looked at the relationship between BMI and two different cholesterol measures, including total cholesterol and low density lipoprotein (LDL) cholesterol, i.e. "bad" cholesterol.

For this study, children were classified as overweight if their BMI was between the 85th and 95th percentiles, and defined as obese if their BMI was greater than the 95th percentile for weight based on age and height. Children had abnormal levels if they had a total cholesterol greater than 200 mg/dl or LDL cholesterol level of greater than 130 mg/dl.

This study found that screening all overweight or obese children would identify approximately 50% of children with abnormal cholesterol levels but would also lead to unnecessary testing for up to 30% of children.

Other studies have looked at additional screening strategies for abnormal cholesterol in children on the basis of having a family history of early heart disease or high cholesterol. But as Lee notes, "A positive family history also performs poorly for identifying children with high cholesterol levels. Therefore, it may be more efficient for the AAP to recommend a public health campaign to reduce cholesterol among all children, rather than screening high-risk groups."

In addition to Lee and Davis, co-authors include Achamyeleh Gebremariam, MS, from the University of Michigan, and colleagues from the Arkansas Center for Health Improvement, including Paula Card-Higginson, BA, ELS, Jennifer L. Shaw, DrPH, MPH, MAP, and Joseph W. Thompson, MD, MPH.

This work was funded by the Robert Wood Johnson Foundation. Dr. Lee was also supported by NIDDK K08DK082386 and the Clinical Sciences Scholars Program at the University of Michigan.

Anne Rueter | EurekAlert!
Further information:
http://www.umich.edu

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>