Physicists at The University of Texas at Arlington have shown that using microwaves to activate photosensitive nanoparticles produces tissue-heating effects that ultimately lead to cell death within solid tumors.
"Our new method using microwaves can propagate through all types of tissues and target deeply situated tumors," said Wei Chen, UTA professor of physics and lead author of the study published this month in he Journal of Biomedical Nanotechnology titled "A new modality of cancer treatment-nanoparticle mediated microwave induced photodynamic therapy."
Photodynamic therapy kills cancer cells when a nanoparticle introduced into tumor tissue generates toxic singlet oxygen after being exposed to light. Singlet oxygen is a highly reactive type of oxygen that irreversibly damages cell mitochondria and eventually causes cell death.
"Up to now, photodynamic therapy, which depends on visible, ultraviolet or near infrared light, was considered effective for skin cancers or cancers close to the skin surface," Chen said. "Our new concept combining microwaves with photodynamic therapy opens up new avenues for targeting deeper tumors and has already proven effective in rapidly and safely reducing tumor size."
In prior studies, the researchers had identified a new type of nanoparticle, copper-cysteamine or Cu-Cy, that could be activated by X-rays to produce singlet oxygen and slow the growth of tumors. X-ray radiation, however, poses significant risks to patients and can harm healthy tissue.
In this new lab study, the team demonstrated that the nanoparticle Cu-Cy also can be activated by microwaves, which can be targeted directly at the tumor itself without harming surrounding tissue.
"Our new microwave-induced photodynamic therapy offers numerous advantages, the most significant of which is increased safety," Chen said. "Our nanoparticle Cu-Cy also demonstrates very low toxicity, is easy to make and inexpensive, and also emits intense luminescence, which means it can also be used as an imaging agent."
The researchers demonstrated that both in vitro and in vivo studies on an osteosarcoma cell line showed significant cell destruction using copper cysteamine nanoparticles under microwave activation. The heating effects and the release of copper ions from copper cysteamine upon activation was the main mechanism for the generation of the reactive oxygen needed for cancer cell destruction.
Chen was joined on this research by Lun Ma, a UTA research assistant professor in physics, as well as Mengyu Yao, Lihua Li and Yu Zhang from the Guangdong Key Laboratory of Orthopaedic Technology and Implant Materials in Guangzhou, China, and Junying Zhang from the Physics Department at Beihang University in Beijing, China. The U.S. Army Medical Research Acquisition Activity, the National Science Foundation and Department of Homeland Security's joint Academic Research Initiative program, the National Basic Research Program of China, the National Natural Science Foundation of China and the five-year plan of the Chinese Military, all supported this research.
"This new invention is largely based on the new photosensitizer copper cysteamine that we invented and patented, and I would like to thank all our team members, particularly Dr. Lun Ma, for the time and energy spent on this project," Chen said.
Alex Weiss, UTA chair of the Physics Department, emphasized the importance of this research in the context of UTA's increasing focus on health and the human condition within the Strategic Plan 2020: Bold Solutions|Global Impact.
"Dr. Chen's research into nanoparticle activation has led to important discoveries that could potentially transform cancer treatment," Weiss said. "This new paper on the possibilities of microwave activation demonstrates yet again how Dr. Chen's search for new modalities of therapy could play a key role in finding safe, viable and inexpensive treatments for cancer."
Chen came to UTA in 2006 following an international career in the United States, Canada, Sweden and China. He received his doctorate in chemistry from Peking University in Beijing, China.
About The University of Texas at Arlington
The University of Texas at Arlington is a Carnegie Research-1 "highest research activity" institution of about 55,000 students in campus-based and online degree programs and is the second-largest institution in The University of Texas System. U.S. News & World Report ranks UTA fifth in the nation for undergraduate diversity. The University is a Hispanic-Serving Institution and is ranked as the top four-year college in Texas for veterans on Military Times' 2016 Best for Vets list. Visit http://www.
For more on the Strategic Plan, see Strategic Plan 2020: Bold Solutions | Global Impact.
Louisa Kellie | EurekAlert!
Photoactive bacteria bait may help in fight against MRSA infections
12.10.2018 | Purdue University
15 emerging technologies that could reduce global catastrophic biological risks
10.10.2018 | Johns Hopkins Center for Health Security
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
New measurement method allows researchers to precisely follow the movement of individual molecules over long periods of time
The function of proteins – the molecular tools of the cell – is governed by the interplay of their structure and dynamics. Advances in electron microscopy have...
16.10.2018 | Event News
02.10.2018 | Event News
01.10.2018 | Event News
16.10.2018 | Life Sciences
16.10.2018 | Physics and Astronomy
16.10.2018 | Event News