Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New potential cancer treatment using microwaves to target deep tumors

12.10.2016

Physicists at The University of Texas at Arlington have shown that using microwaves to activate photosensitive nanoparticles produces tissue-heating effects that ultimately lead to cell death within solid tumors.

"Our new method using microwaves can propagate through all types of tissues and target deeply situated tumors," said Wei Chen, UTA professor of physics and lead author of the study published this month in he Journal of Biomedical Nanotechnology titled "A new modality of cancer treatment-nanoparticle mediated microwave induced photodynamic therapy."


This is a figure explaining the new method.

Credit: UTA

Photodynamic therapy kills cancer cells when a nanoparticle introduced into tumor tissue generates toxic singlet oxygen after being exposed to light. Singlet oxygen is a highly reactive type of oxygen that irreversibly damages cell mitochondria and eventually causes cell death.

"Up to now, photodynamic therapy, which depends on visible, ultraviolet or near infrared light, was considered effective for skin cancers or cancers close to the skin surface," Chen said. "Our new concept combining microwaves with photodynamic therapy opens up new avenues for targeting deeper tumors and has already proven effective in rapidly and safely reducing tumor size."

... more about:
»COPPER »microwaves »nanoparticle »tumors

In prior studies, the researchers had identified a new type of nanoparticle, copper-cysteamine or Cu-Cy, that could be activated by X-rays to produce singlet oxygen and slow the growth of tumors. X-ray radiation, however, poses significant risks to patients and can harm healthy tissue.

In this new lab study, the team demonstrated that the nanoparticle Cu-Cy also can be activated by microwaves, which can be targeted directly at the tumor itself without harming surrounding tissue.

"Our new microwave-induced photodynamic therapy offers numerous advantages, the most significant of which is increased safety," Chen said. "Our nanoparticle Cu-Cy also demonstrates very low toxicity, is easy to make and inexpensive, and also emits intense luminescence, which means it can also be used as an imaging agent."

The researchers demonstrated that both in vitro and in vivo studies on an osteosarcoma cell line showed significant cell destruction using copper cysteamine nanoparticles under microwave activation. The heating effects and the release of copper ions from copper cysteamine upon activation was the main mechanism for the generation of the reactive oxygen needed for cancer cell destruction.

Chen was joined on this research by Lun Ma, a UTA research assistant professor in physics, as well as Mengyu Yao, Lihua Li and Yu Zhang from the Guangdong Key Laboratory of Orthopaedic Technology and Implant Materials in Guangzhou, China, and Junying Zhang from the Physics Department at Beihang University in Beijing, China. The U.S. Army Medical Research Acquisition Activity, the National Science Foundation and Department of Homeland Security's joint Academic Research Initiative program, the National Basic Research Program of China, the National Natural Science Foundation of China and the five-year plan of the Chinese Military, all supported this research.

"This new invention is largely based on the new photosensitizer copper cysteamine that we invented and patented, and I would like to thank all our team members, particularly Dr. Lun Ma, for the time and energy spent on this project," Chen said.

Alex Weiss, UTA chair of the Physics Department, emphasized the importance of this research in the context of UTA's increasing focus on health and the human condition within the Strategic Plan 2020: Bold Solutions|Global Impact.

"Dr. Chen's research into nanoparticle activation has led to important discoveries that could potentially transform cancer treatment," Weiss said.  "This new paper on the possibilities of microwave activation demonstrates yet again how Dr. Chen's search for new modalities of therapy could play a key role in finding safe, viable and inexpensive treatments for cancer."

###

Chen came to UTA in 2006 following an international career in the United States, Canada, Sweden and China. He received his doctorate in chemistry from Peking University in Beijing, China.

About The University of Texas at Arlington

The University of Texas at Arlington is a Carnegie Research-1 "highest research activity" institution of about 55,000 students in campus-based and online degree programs and is the second-largest institution in The University of Texas System. U.S. News & World Report ranks UTA fifth in the nation for undergraduate diversity. The University is a Hispanic-Serving Institution and is ranked as the top four-year college in Texas for veterans on Military Times' 2016 Best for Vets list. Visit http://www.uta.edu to learn more, and find UTA rankings and recognition at http://www.uta.edu/uta/about/rankings.php.

For more on the Strategic Plan, see Strategic Plan 2020: Bold Solutions | Global Impact.

Media Contact

Louisa Kellie
louisa.kellie@uta.edu
817-524-8926

 @utarlington

http://www.uta.edu 

Louisa Kellie | EurekAlert!

Further reports about: COPPER microwaves nanoparticle tumors

More articles from Health and Medicine:

nachricht Scientists discover the basics of how pressure-sensing Piezo proteins work
22.08.2019 | Weill Cornell Medicine

nachricht Protein-transport discovery may help define new strategies for treating eye disease
22.08.2019 | Scripps Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Hamburg and Kiel researchers observe spontaneous occurrence of skyrmions in atomically thin cobalt films

Since their experimental discovery, magnetic skyrmions - tiny magnetic knots - have moved into the focus of research. Scientists from Hamburg and Kiel have now been able to show that individual magnetic skyrmions with a diameter of only a few nanometres can be stabilised in magnetic metal films even without an external magnetic field. They report on their discovery in the journal Nature Communications.

The existence of magnetic skyrmions as particle-like objects was predicted 30 years ago by theoretical physicists, but could only be proven experimentally in...

Im Focus: Physicists create world's smallest engine

Theoretical physicists at Trinity College Dublin are among an international collaboration that has built the world's smallest engine - which, as a single calcium ion, is approximately ten billion times smaller than a car engine.

Work performed by Professor John Goold's QuSys group in Trinity's School of Physics describes the science behind this tiny motor.

Im Focus: Quantum computers to become portable

Together with the University of Innsbruck, the ETH Zurich and Interactive Fully Electrical Vehicles SRL, Infineon Austria is researching specific questions on the commercial use of quantum computers. With new innovations in design and manufacturing, the partners from universities and industry want to develop affordable components for quantum computers.

Ion traps have proven to be a very successful technology for the control and manipulation of quantum particles. Today, they form the heart of the first...

Im Focus: Towards an 'orrery' for quantum gauge theory

Experimental progress towards engineering quantized gauge fields coupled to ultracold matter promises a versatile platform to tackle problems ranging from condensed-matter to high-energy physics

The interaction between fields and matter is a recurring theme throughout physics. Classical cases such as the trajectories of one celestial body moving in the...

Im Focus: A miniature stretchable pump for the next generation of soft robots

Soft robots have a distinct advantage over their rigid forebears: they can adapt to complex environments, handle fragile objects and interact safely with humans. Made from silicone, rubber or other stretchable polymers, they are ideal for use in rehabilitation exoskeletons and robotic clothing. Soft bio-inspired robots could one day be deployed to explore remote or dangerous environments.

Most soft robots are actuated by rigid, noisy pumps that push fluids into the machines' moving parts. Because they are connected to these bulky pumps by tubes,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The power of thought – the key to success: CYBATHLON BCI Series 2019

16.08.2019 | Event News

4th Hybrid Materials and Structures 2020 28 - 29 April 2020, Karlsruhe, Germany

14.08.2019 | Event News

What will the digital city of the future look like? City Science Summit on 1st and 2nd October 2019 in Hamburg

12.08.2019 | Event News

 
Latest News

Making small intestine endoscopy faster with a pill-sized high-tech camera

23.08.2019 | Medical Engineering

More reliable operation offshore wind farms

23.08.2019 | Power and Electrical Engineering

Tracing the evolution of vision

23.08.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>