Charcot reported improvements in his patients, but he died shortly thereafter and a more complete evaluation of the therapy was never conducted. Now, a group of neurological researchers at Rush University Medical Center have replicated his work in a study to see if Charcot’s observation holds true against modern scientific testing.
Results from the study indicate that while vibration therapy does significantly improve some symptoms of Parkinson’s disease, the effect is due to placebo or other nonspecific factors, and not the vibration. The findings are published in the April issue of Journal of Parkinson’s Disease.
“We attempted to mimic Charcot’s protocol with modern equipment in order to confirm or refute an historical observation,” explains lead investigator Christopher G. Goetz, MD, director of the Parkinson’s disease and Movement Disorders Center at Rush. “Both the treated group and the control group improved similarly, suggesting other factors had an effect on Parkinson’s disease motor function.”
Charcot’s patients told him that during long carriage rides or train journeys, uncomfortable or painful symptoms of Parkinson’s disease seemed to disappear, and the relief lasted quite some time after the journey. He developed a chair that mimicked the continuous jerking of a carriage or train.
Goetz and his colleagues randomly assigned 23 patients to either a vibrating chair or the same chair without vibration. During the treatment sessions, both groups of study participants listened to a relaxation CD of nature sounds. Study participants underwent daily treatment for a month.
The patients in the vibration treatment group showed significant improvement in motor function after daily 30-minute treatments for four weeks. Although not as high, motor function scores for the no vibration group also improved significantly. Both groups showed similar and significant improvement in depression, anxiety, fatigue, and nighttime sleep and both groups reported similar high satisfaction with their treatment.
“Our results confirm Charcot’s observation of improvement in Parkinson’s disease symptomology with chronic vibration treatment, but we did not find the effect specific to vibration,” said Goetz. “Instead, our data suggest that auditory sensory stimulation with relaxation in a lounge chair or simply the participation in a research protocol has equivalent benefit as vibration on motor function.”
“While we can agree that our results may not change scientific thinking on treatment mechanisms, our results will allow clinicians to guide patients to at least one apparatus that is safe and associated with objective changes in parkinsonian impairment scores,” said Goetz. “Charcot’s advice to colleagues resonates as one places vibration therapy in the context of potential options for patients. ‘It is no small gain to be able to relieve the sufferers of paralysis agitans.’”
Deb Song | EurekAlert!
Live probiotics can re-balance the gut microbiome and modify immune system response
20.11.2018 | Symprove
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
20.11.2018 | Life Sciences
20.11.2018 | Life Sciences
20.11.2018 | Ecology, The Environment and Conservation