Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks
A new study by Lyle Hood, assistant professor of mechanical engineering at The University of Texas at San Antonio (UTSA), describes a new device that could revolutionize the delivery of medicine to treat cancer as well as a host of other diseases and ailments. Hood developed the device in partnership with Alessandro Grattoni, chair of the Department of Nanomedicine at Houston Methodist Research Institute.
"The problem with most drug-delivery systems is that you have a specific minimum dosage of medicine that you need to take for it to be effective," Hood said. "There's also a limit to how much of the drug can be present in your system so that it doesn't make you sick."
As a result of these limitations, a person who needs frequent doses of a specific medicine is required to take a pill every day or visit a doctor for injections. Hood's creation negates the need for either of these approaches, because it's a tiny implantable drug delivery system.
"It's an implantable capsule, filled with medicinal fluid that uses about 5000 nanochannels to regulate the rate of release of the medicine," Hood said. "This way, we have the proper amount of drugs in a person's system to be effective, but not so much that they'll harm that person."
The capsule can deliver medicinal doses for several days or a few weeks. According to Hood, it can be used for any kind of ailment that needs a localized delivery over several days or a few weeks. This makes it especially tailored for treating cancer, while a larger version of the device, which was originally created by Grattoni, can treat diseases like HIV for up to a year.
"In HIV treatment, you can bombard the virus with drugs to the point that that person is no longer infectious and shows no symptoms," Hood said. "The danger is that if that person stops taking their drugs, the amount of medicine in his or her system drops below the effective dose and the virus is able to become resistant to the treatments."
The capsule, however, could provide a constant delivery of the HIV-battling drugs to prevent such an outcome. Hood noted it can also be used to deliver cortisone to damaged joints to avoid painful, frequent injections, and possibly even to pursue immunotherapy treatments for cancer patients.
"The idea behind immunotherapy is to deliver a cocktail of immune drugs to call attention to the cancer in a person's body, so the immune system will be inspired to get rid of the cancer itself," he said.
The current prototype of the device is permanent and injected under the skin, but Hood is working with Teja Guda, assistant professor of biomedical engineering, to collaborate on 3-D printing technology to make a new, fully biodegradable iteration of the device that could potentially be swallowed.
Joanna Carver | EurekAlert!
Smartphones as ophthalmoscopes save sight: Cost-effective telemedical eye screening of people with diabetes in India
09.07.2019 | Rheinische Friedrich-Wilhelms-Universität Bonn
Shorter courses of proton therapy can be just as effective as full courses prostate cancer
08.07.2019 | University of Pennsylvania School of Medicine
Adjusting the thermal conductivity of materials is one of the challenges nanoscience is currently facing. Together with colleagues from the Netherlands and Spain, researchers from the University of Basel have shown that the atomic vibrations that determine heat generation in nanowires can be controlled through the arrangement of atoms alone. The scientists will publish the results shortly in the journal Nano Letters.
In the electronics and computer industry, components are becoming ever smaller and more powerful. However, there are problems with the heat generation. It is...
Scientists have visualised the electronic structure in a microelectronic device for the first time, opening up opportunities for finely-tuned high performance electronic devices.
Physicists from the University of Warwick and the University of Washington have developed a technique to measure the energy and momentum of electrons in...
Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in July in the Journal “Haematologica”.
Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The bone marrow produces all types of blood cells: red...
For some phenomena in quantum many-body physics several competing theories exist. But which of them describes a quantum phenomenon best? A team of researchers from the Technical University of Munich (TUM) and Harvard University in the United States has now successfully deployed artificial neural networks for image analysis of quantum systems.
Is that a dog or a cat? Such a classification is a prime example of machine learning: artificial neural networks can be trained to analyze images by looking...
An international research group led by scientists from the University of Bayreuth has produced a previously unknown material: Rhenium nitride pernitride. Thanks to combining properties that were previously considered incompatible, it looks set to become highly attractive for technological applications. Indeed, it is a super-hard metallic conductor that can withstand extremely high pressures like a diamond. A process now developed in Bayreuth opens up the possibility of producing rhenium nitride pernitride and other technologically interesting materials in sufficiently large quantity for their properties characterisation. The new findings are presented in "Nature Communications".
The possibility of finding a compound that was metallically conductive, super-hard, and ultra-incompressible was long considered unlikely in science. It was...
24.06.2019 | Event News
29.04.2019 | Event News
17.04.2019 | Event News
19.07.2019 | Physics and Astronomy
19.07.2019 | Physics and Astronomy
19.07.2019 | Earth Sciences