Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rice University technology in human trials to spot cardiac disease, cancer, drug abuse

10.02.2011
Diagnostic chip may help hearts, cut costs

Heart disease is a silent killer, but new microchip technology from Rice University is expected to advance the art of diagnosis.

During National Heart Health Month, Rice Professor John McDevitt will discuss the potential of this technology to detect cardiac disease early at the annual meeting of the American Association for the Advancement of Science (AAAS) in Washington, D.C., Feb. 17-21. Cardiac disease is the focus of one of six ongoing major clinical trials of Rice's programmable bio-nano-chips (PBNCs).

PBNCs combine microfluidics, nanotechnology, advanced optics and electronics to enable quick, painless diagnostic tests for a wide range of diseases at minimal cost.

Current clinical trials employ PBNCs to test more than 4,000 patients for signs of heart disease, ovarian cancer, prostate cancer, oral cancer and drug abuse. Versions to test for HIV/AIDS and other diseases are also in development.

"Too often, the first time people know they're suffering from heart disease is when it kills them," said McDevitt, Rice's Brown-Wiess Professor of Chemistry and Bioengineering, who will participate in a global health seminar at AAAS.

"With this test, we expect to save lives and dramatically cut the recovery time and cost of caring for those who suffer from heart ailments," said McDevitt, a pioneer in the creation of microfluidic devices for biomedical testing. He anticipates the PBNCs, when manufactured in bulk, will cost only a few dollars each.

PBNCs analyze a patient's saliva for biomarkers associated with cardiovascular disease. Unfortunately, McDevitt said, only about half of the patients having a heart attack are diagnosed immediately via electrocardiogram. The rest require a series of time-consuming laboratory tests that take up to 12 hours to complete. PBNCs now in development deliver results in as little as 20 minutes and provide clinicians with timely information that can help them manage patients more effectively.

"A critical thing to recognize in a heart attack is that if we're able to open the blocked vessel within an hour, we've salvaged a heart muscle," said Biykem Bozkurt, the Mary and Gordon Cain Chair and Professor of Medicine and director of the Winters Center for Heart Failure Research at Baylor College of Medicine (BCM). "Thus, the patient's chance of survival is significantly improved."

Bozkurt and Christie Ballantyne, chief of atherosclerosis and vascular medicine and professor of medicine at BCM and director of the Center for Cardiovascular Disease Prevention at the Methodist DeBakey Heart and Vascular Center, are leading the trial at Houston's Michael E. DeBakey VA Medical Center, one of four sites hosting the cardiac trial that will recruit 1,000 patients.

McDevitt noted that of 5 million visits to American emergency rooms each year for chest pain, approximately 80 percent are false alarms.

"We have patients clogging the ER system and delaying the recognition of true heart attack cases because we can't, in an expeditious manner, rule out false alarms that could have been diagnosed in the ambulance or the home setting," said Bozkurt, who also serves as cardiology section chief at the VA.

The potential cost savings for even a single patient are tremendous, said Vivian Ho, the James A. Baker III Institute Chair in Health Economics and a professor of economics at Rice.

"Treating patients in the emergency room is one of the highest costs we have in the health care system," Ho said, "particularly for heart attacks, because heart disease is the leading killer of Americans and it accounts for a large proportion of our health care costs.

"If we can identify these patients quickly so we can avoid aggressive diagnostic tests further on down the road -- for example, cardiac catheterizations and procedures that cost tens of thousands of dollars -- by instead using a relatively low-cost diagnostic chip, that's a tremendous opportunity to provide better care and lower costs," she said.

McDevitt expects PBNCs and their toaster-sized reader will ultimately find a place at many points of care -- hospitals, doctors' or dentists' offices, pharmacies and remote clinics worldwide -- where they will allow clinicians to quickly diagnose a variety of ailments.

He anticipates Rice's BioScience Research Collaborative, part of the Texas Medical Center, to be the hub of a pipeline in which chips will be programmed to spot biomarkers for many important diseases.

"PNBC technology marries medical devices and microelectronics," McDevitt said, "and it has the potential to revolutionize the flow of information in the practice of medicine while significantly reducing cost. I like to think of it as the iPhone of medicine, with the same potential to be a game changer. And it's just around the corner."

Related materials:

Video with a short discussion and demonstration of the technology is available at http://www.youtube.com/watch?v=I084_NjNP5U.

Located in Houston, Rice University is consistently ranked among the nation's top 20 universities by U.S. News & World Report. A Tier One research university known for its "unconventional wisdom," Rice has schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and offers its 3,485 undergraduates and 2,275 graduate students a wide range of majors. Rice has the sixth-largest endowment per student among American private research universities and is rated No. 4 for "best value" among private universities by Kiplinger's Personal Finance. Its undergraduate student-to-faculty ratio is less than 6-to-1. With a residential college system that builds close-knit and diverse communities and collaborative culture, Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review.

David Ruth | EurekAlert!
Further information:
http://www.rice.edu

More articles from Medical Engineering:

nachricht Can radar replace stethoscopes?
14.08.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht Novel PET imaging method could track and guide therapy for type 1 diabetes
03.08.2018 | Society of Nuclear Medicine and Molecular Imaging

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>