Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma

02.05.2012
Low dose whole body CT is nearly four times better than radiographic skeletal survey, the standard of care in the U.S., for determining the extent of disease in patients with multiple myeloma, a new study shows.

The study, conducted at the University of Maryland in Baltimore, included 51 patients who had both a radiographic skeletal survey as well as a low dose whole body CT examination. The total number of lesions detected in these patients with low dose whole body CT was 968 versus 248 detected by radiographic skeletal survey, said Kelechi Princewill, MD, the lead author of the study.

"The stage of disease determines treatment, and the study found that in 31 patients, the stage of disease would have been different with low dose whole body CT. Thirteen patients would have been upstaged from stage I to stage II; nine patients would have been upstaged from stage I to stage III and nine patients would have been upstaged from stage II to III based on additional lesions detected on the low dose whole body CT," said Dr. Princewill.

Low dose whole body CT was significantly better than radiographic skeletal survey in detecting lesions in the spine, ribs, sternum and flat bones, added Dr. Princewill.

The use of low dose whole body CT is accepted in Europe as an accurate alternative to radiographic skeletal survey for detecting bone lesions in these patients, said Dr. Princewill. A concern about radiation dose may be one of the reasons why it is not widely accepted in the U.S., he said. "Our study employed a low dose protocol, with an average recorded CT dose of 4.1 mSv. That compares to 1.8 mSv for the radiographic skeletal survey. Using modified protocols and exposure parameters, we were able to significantly reduce the radiation doses to our patients without significantly compromising the image quality required to detect myeloma lesions. The average CT dose used in our study was approximately nine times lower than doses used in the acquisition of standard body CT studies," Dr. Princewill said.
The study is being presented on May 2 at the American Roentgen Ray Society annual meeting in Vancouver, Canada.

About ARRS

The American Roentgen Ray Society (ARRS) was founded in 1900 and is the oldest radiology society in the United States. Its monthly journal, the American Journal of Roentgenology, began publication in 1906. Radiologists from all over the world attend the ARRS Annual Meeting to take part in instructional courses, scientific paper presentations and scientific and commercial exhibits related to the field of radiology. The Society is named after the first Nobel Laureate in Physics, Wilhelm Röentgen, who discovered the X-ray in 1895.

Samantha Schmidt | EurekAlert!
Further information:
http://www.arrs.org

More articles from Medical Engineering:

nachricht LISA: Scientists introduce a new method of statistical inference in neuroimaging (fMRI)
16.10.2018 | Max-Planck-Institut für biologische Kybernetik

nachricht Researchers demonstrate first example of a bioelectronic medicine
09.10.2018 | Northwestern University

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Goodbye, silicon? On the way to new electronic materials with metal-organic networks

Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.

Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...

Im Focus: Storage & Transport of highly volatile Gases made safer & cheaper by the use of “Kinetic Trapping"

Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles

Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...

Im Focus: Disrupting crystalline order to restore superfluidity

When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.

We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...

Im Focus: Micro energy harvesters for the Internet of Things

Fraunhofer IWS Dresden scientists print electronic layers with polymer ink

Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...

Im Focus: Dynamik einzelner Proteine

Neue Messmethode erlaubt es Forschenden, die Bewegung von Molekülen lange und genau zu verfolgen

Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Conference to pave the way for new therapies

17.10.2018 | Event News

Berlin5GWeek: Private industrial networks and temporary 5G connectivity islands

16.10.2018 | Event News

5th International Conference on Cellular Materials (CellMAT), Scientific Programme online

02.10.2018 | Event News

 
Latest News

Nanocages in the lab and in the computer: how DNA-based dendrimers transport nanoparticles

19.10.2018 | Life Sciences

Thin films from Braunschweig on the way to Mercury

19.10.2018 | Physics and Astronomy

App-App-Hooray! - Innovative Kits for AR Applications

19.10.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>