Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists reveal rules for making ribs

29.11.2017

Scientists from the USC Stem Cell lab of Francesca Mariani recently shared a recipe for ribs, and it doesn't even require barbecue sauce.

In a new publication in the journal eLife, first authors Jennifer Fogel from USC, Daniel Lakeland from Lakeland Applied Sciences and colleagues examine the development of the vertebrate ribcage, which supports the body, protects the internal organs and enables life on land.


Mouse rib cage stained to show cartilage (blue) and bone (red)

Credit: Francesca Mariani

In the study, the authors describe a simple computational tool that models the choices cells make while the ribcage develops in the early mouse embryo. Some cells choose to become the bony section of each rib that connects to the spine, while other cells choose to form the cartilage section of each rib that joins the sternum. Understanding this process required the team to integrate the effects of cell growth, cell death, and cell communication into their computational tool in order to gain insights into how the skeleton forms.

Using the model, the scientists propose that the different levels of a secreted protein called Hedgehog (Hh) are important for cells to make the decision to form bone or cartilage. High levels of Hh bias the cells towards making the bone component. As Hh travels further away from its source at the midline of the back, concentrations of Hh drop. Lower concentrations bias the cells towards making the more distant cartilage component of each rib.

Each cell's decision to contribute to the bone or cartilage component is likely locked-in early when the embryo is very small, and maintained as the embryo grows exponentially.

"Our study suggests that regardless of whether an embryo gives rise to a large elephant or a small mouse, that the rib skeleton has already organized itself while the embryo is smaller than a grain of rice," explained Mariani, assistant professor of stem cell biology and regenerative medicine and principal investigator in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. "In addition, the modeling approach we developed can be used to understand the challenges of building new tissues in adults after injury."

###

In Kyoung Mah from USC also contributed to the study. Funding came from the University of Southern California, and NIH NIAMS. Fogel was supported by a postdoctoral fellowship from the California Institute for Regenerative Medicine.

Media Contact

Zen Vuong
zvuong@usc.edu
213-300-1381

 @keckmedusc

http://www.keckmedicine.org/ 

Zen Vuong | EurekAlert!

More articles from Life Sciences:

nachricht Turning carbon dioxide into liquid fuel
06.08.2020 | DOE/Argonne National Laboratory

nachricht Tellurium makes the difference
06.08.2020 | Friedrich-Schiller-Universität Jena

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: ScanCut project completed: laser cutting enables more intricate plug connector designs

Scientists at the Fraunhofer Institute for Laser Technology ILT have come up with a striking new addition to contact stamping technologies in the ERDF research project ScanCut. In collaboration with industry partners from North Rhine-Westphalia, the Aachen-based team of researchers developed a hybrid manufacturing process for the laser cutting of thin-walled metal strips. This new process makes it possible to fabricate even the tiniest details of contact parts in an eco-friendly, high-precision and efficient manner.

Plug connectors are tiny and, at first glance, unremarkable – yet modern vehicles would be unable to function without them. Several thousand plug connectors...

Im Focus: New Strategy Against Osteoporosis

An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.

Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...

Im Focus: AI & single-cell genomics

New software predicts cell fate

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...

Im Focus: TU Graz Researchers synthesize nanoparticles tailored for special applications

“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.

Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...

Im Focus: Tailored light inspired by nature

An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.

Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“Conference on Laser Polishing – LaP 2020”: The final touches for surfaces

23.07.2020 | Event News

Conference radar for cybersecurity

21.07.2020 | Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

 
Latest News

Rare Earth Elements in Norwegian Fjords?

06.08.2020 | Earth Sciences

Anode material for safe batteries with a long cycle life

06.08.2020 | Power and Electrical Engineering

Turning carbon dioxide into liquid fuel

06.08.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>