Cisplatin is a common platinum-based cancer drug. But while cisplatin kills cancer cells, it also attacks healthy cells, causing debilitating side effects. Ruthenium is a rare transition metal also belonging to the platinum group of the periodic table, and the UK researchers developed two new ruthenium complexes designed to kill cancer cells while preserving healthy cells.
These complexes are inert in the dark, but when activated with light, they become up to 200 times as toxic, and up to three times as potent as cisplatin against tumor cells.
Published in the Journal of the American Chemical Society, the study examined the effects of these new complexes on lung cancer and leukemia cells. Edith Glazer, UK assistant professor of chemistry and principal investigator for the study, hopes to move these compounds forward in more biological testing soon.
"Coordination chemistry has proven to be an elegant method to rapidly synthesize a family of molecules," Glazer said. "We anticipate that this will prove advantageous in allowing us to make chemical modifications to optimize properties as needed as we move forward into animal studies."
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UNH researchers create a more effective hydrogel for healing wounds
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Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.
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Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
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