Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research highlights possible targets to help tackle Crohn's disease

18.06.2019

The research has focused on different types of cells called macrophages, and how they work when bacteria are present

Affecting around 115,000 people in the UK alone, Crohn's Disease is a lifelong condition which sees parts of the digestive system become inflamed. There is no precise cure and causes are believed to vary.


A scanning electron microscopy image of a macrophage, total magnification x5500.

Credit: University of Plymouth

But one indicator of the condition - an abnormal reaction of the immune system to certain bacteria in the intestines - has had new light shed on it thanks to scientists at the University of Plymouth.

The research has focused on different types of cells called macrophages, which are part of our immune system and are found in most tissues, where they patrol for potential harmful organisms and destroy them.

In inflammatory diseases, like Crohn's, macrophages mediate the inflammatory destruction of the gut. Just how the tissue reacts (inflammation or suppression) is dependent on the type of macrophage cell present, and how it is stimulated - and scientists have been trying to get to the bottom of this.

The new research has shown how different types of macrophage - one type being pro-inflammatory and the other being anti-inflammatory - exhibit quite different molecular mechanisms involved in switching off their functional behaviour when bacteria are present.

And this difference, as study author Dr Andrew Foey explains, highlights the possibility of targeting and selectively suppressing the pro-inflammatory cells that drive diseases such as Crohn's Disease.

"This small step in understanding of differential off-signalling of macrophage type may go hand-in-hand with understanding the relapsing/remitting presentation of Crohn's Disease," he said. "It is suggestive of future research endeavours in targeting macrophage responses in the treatment of inflammatory diseases - and it's a really positive step."

The full study, entitled 'Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip' is available to view in the journal PLOS ONE (doi: 10.1371/journal.pone.0214681).

The research was led by Dr Andrew Foey with Dr Khalid AlShaghdali and PhD student Barbara Durante from the School of Biomedical Sciences at the University of Plymouth, in collaboration with Dr Jane Beal, from the School of Biological and Marine Sciences.

Infection, Immunity and Inflammation is one of the key research themes in the Institute of Translational and Stratified Medicine (ITSMed) at the University of Plymouth.

The work was funded by University of Hail, Kingdom of Saudi Arabia.

Amy King | EurekAlert!
Further information:
http://dx.doi.org/10.1371/journal.pone.0214681

More articles from Life Sciences:

nachricht Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow
16.07.2019 | Rudolf-Virchow-Zentrum für Experimentelle Biomedizin der Universität Würzburg

nachricht A human liver cell atlas
15.07.2019 | Max Planck Institute of Immunobiology and Epigenetics

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow

Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in July in the Journal “Haematologica”.

Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The bone marrow produces all types of blood cells: red...

Im Focus: Artificial neural network resolves puzzles from condensed matter physics: Which is the perfect quantum theory?

For some phenomena in quantum many-body physics several competing theories exist. But which of them describes a quantum phenomenon best? A team of researchers from the Technical University of Munich (TUM) and Harvard University in the United States has now successfully deployed artificial neural networks for image analysis of quantum systems.

Is that a dog or a cat? Such a classification is a prime example of machine learning: artificial neural networks can be trained to analyze images by looking...

Im Focus: Extremely hard yet metallically conductive: Bayreuth researchers develop novel material with high-tech prospects

An international research group led by scientists from the University of Bayreuth has produced a previously unknown material: Rhenium nitride pernitride. Thanks to combining properties that were previously considered incompatible, it looks set to become highly attractive for technological applications. Indeed, it is a super-hard metallic conductor that can withstand extremely high pressures like a diamond. A process now developed in Bayreuth opens up the possibility of producing rhenium nitride pernitride and other technologically interesting materials in sufficiently large quantity for their properties characterisation. The new findings are presented in "Nature Communications".

The possibility of finding a compound that was metallically conductive, super-hard, and ultra-incompressible was long considered unlikely in science. It was...

Im Focus: Modelling leads to the optimum size for platinum fuel cell catalysts: Activity of fuel cell catalysts doubled

An interdisciplinary research team at the Technical University of Munich (TUM) has built platinum nanoparticles for catalysis in fuel cells: The new size-optimized catalysts are twice as good as the best process commercially available today.

Fuel cells may well replace batteries as the power source for electric cars. They consume hydrogen, a gas which could be produced for example using surplus...

Im Focus: The secret of mushroom colors

Mushrooms: Darker fruiting bodies in cold climates

The fly agaric with its red hat is perhaps the most evocative of the diverse and variously colored mushroom species. Hitherto, the purpose of these colors was...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on UV LED Technologies & Applications – ICULTA 2020 | Call for Abstracts

24.06.2019 | Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

 
Latest News

Flying Laptop satellite mission extended by two years - Successfully in orbit since July 14, 2017

16.07.2019 | Physics and Astronomy

New safer, inexpensive way to propel small satellites

16.07.2019 | Power and Electrical Engineering

UCI electrical engineering team develops 'beyond 5G' wireless transceiver

16.07.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>