Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Purified bacterial extract sprayed into lungs ramps up innate immune system

04.12.2007
Providing powerful protection from inhaled deadly pathogens

A purified extract prepared from a common microbe and delivered to the lungs of laboratory mice in a spray set off a healthy immune response and provided powerful protection against all four major classes of pathogens including those responsible for anthrax and bubonic plague, according to a presentation at the American Society for Cell Biology’s 47th Annual Meeting.

In addition, when the researchers exposed another group of mice to an aerosol of live Streptococcus pneumoniae, the only animals that survived were the ones that had been pre-treated with the spray. A total of 83 percent of these mice survived. None of the untreated animals lived.

The researchers at the M.D. Anderson Cancer Center in Houston developed the spray from a purified extract of the common coccobacillus named Haemophilus influenzae, the cause of ear and sinus infections in human children.

... more about:
»Pathogen »Spray »extract

Their “aerosolized lung innate immune stimulant,” as the scientists have named the spray treatment, could benefit immune-compromised patients with cancer, HIV or other diseases as well as emergency workers and the general public facing uncommon threats like an aerosolized bioterror attack or a spreading respiratory epidemic.

According to Brenton Scott who with his postdoctoral advisor, Burton Dickey, developed the spray, the treatment works best if administered four to 24 hours before exposure. Nearly all mice survived when treated before exposure to lethal doses of anthrax, influenza, and the dangerous mold, Aspergillus. But, the treatment also has some benefit when given after exposure. Effectiveness declines over time but seems to last up to five days after a single dose.

The researchers report that protection by stimulant is associated with rapid pathogen killing in the airways, does not depend on recruitment of other immune defense cells such as neutrophils, and correlates with increased levels of antimicrobial polypeptides in the lung lining fluid. The host response is localized to the airways, and safety studies indicate that the treatment causes minimal side effects, even with repeated doses.

Preclinical testing is being completed, and clinical trials are being designed.

In tests on mice, the stimulant was protective against all four major classes of pathogens (Gram-positive and Gram-negative bacteria, fungi, and viruses), including the Class A bioterror agents Bacillus anthracis (anthrax), F. tularensis (tularemia) and Yersinia pestis (bubonic plague).

John Fleischman | EurekAlert!
Further information:
http://www.ascb.org

Further reports about: Pathogen Spray extract

More articles from Life Sciences:

nachricht Overlooked molecular machine in cell nucleus may hold key to treating aggressive leukemia
23.04.2019 | Cincinnati Children's Hospital Medical Center

nachricht Bacteria use their enemy -- phage -- for 'self-recognition'
23.04.2019 | Chinese Academy of Sciences Headquarters

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum gas turns supersolid

Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.

Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

Control 2019: Fraunhofer IPT presents high-speed microscope with intuitive gesture control

24.04.2019 | Trade Fair News

Marine Skin dives deeper for better monitoring

23.04.2019 | Information Technology

Geomagnetic jerks finally reproduced and explained

23.04.2019 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>