Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Benefit Of Detrimental Mutations

07.05.2007
The Russian researchers at the Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, and the Center for Demographic Research, Duke University (USA), jointly with their French colleagues have investigated the mutation, the double dose of which causes malignant growths, but a single dose increases stress resistance and prolongs life. Thus, due to the benefits provided by the mutation, the population preserves high risk of cancer.

The overwhelming majority of genes are represented in two copies in the cells of animals: one is received from the mother, the other – from the father. In many cases, the organism endures with difficulty the damage to one of the copies: a single dose of a gene may be insufficient for normal evolution. However, for some genes a single dose is not simply endurable but also welcome. Such cases deal primarily with the genes that increase life span and stress resistance. Individuals with a single normal copy of such gene (the second copy is desperately spoiled as a result of mutation) live longer and better endure unfavorable conditions. But, the owners of a double dose of the mutant gene are either nonviable or more frequently than others die of some disease such as malignant growth.

Investigation of mutations in stress resistance genes is only possible on models, and the researchers worked with drosophilas. They studied the lgl tumor suppressor gene. Human beings have the gene with the same functions, it is called Hugl-1. If normal copies of the gene are absent in the cells, frequency of cancer occurrence is high. It may seem that such detrimental mutation should be abolished by selection, however, the lgl gene mutations are rather frequently found in the population. Why?

It has turned out that the drosophilas containing one mutant copy and one normal copy of the gene possess increased embryonic survival rate if they develop at stressful temperatures (16 and 29 degrees centigrade). At the temperature of 25 degrees (which is optimal for flies), viability of mutation carriers is slightly lower that the one of owners of the double gene dose. Besides, mutation carries have a longer life span. These useful properties become normally apparent in case if mutation was received from the mother. Apparently, increased viability of flies is being formed in the early embryonic evolution stage and depends on the maternal genotype. Mutation carriers are more stable to viral infections.

... more about:
»Cancer »Drosophila »Mutant

Thus, if the gene does not work at all in case of two mutant copies, then probability of cancer development in the organism is high, and a single copy of the gene (in case of one mutant copy) in some way ensures optimal state of the organism in stress conditions.

Cancer development with human beings and animals is a complicated, multi-stag process connected with the loss or damage of certain genes. The drosophila investigations carried out by the Russian researchers help to understand why the mutations that can cause cancer do not disappear from the population but are preserved in it.

Nadezda Markina | alfa
Further information:
http://ww.informnauka.ru

Further reports about: Cancer Drosophila Mutant

More articles from Life Sciences:

nachricht Lethal combination: Drug cocktail turns off the juice to cancer cells
12.12.2018 | Universität Basel

nachricht Smelling the forest – not the trees
12.12.2018 | Universität Konstanz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

New discoveries predict ability to forecast dementia from single molecule

12.12.2018 | Health and Medicine

CCNY-Yale researchers make shape shifting cell breakthrough

12.12.2018 | Physics and Astronomy

Pain: Perception and motor impulses arise in the brain independently of one another

12.12.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>