Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Three new lung tumor subtypes identified in DNA profiling study

01.11.2006
A new study has identified three subtypes of non-small-cell lung cancer tumors, a finding that may provide valuable clinical information about patient survival in early- or late-stage disease, how likely the cancer is to spread and whether the tumor will prove resistant to chemotherapy.

A report of the study, led by researchers at the University of North Carolina at Chapel Hill's Lineberger Comprehensive Cancer Center, appears in the November issue of the Journal of Clinical Oncology.

Currently, lung cancer treatment decisions are based largely on the location and size of the tumor and if it has spread, or metastasized. And, lung tumor cells are diagnosed by their appearance under a microscope. About 20 percent of these tumors are classified as small-cell carcinomas; the rest fall into a catch-all diagnosis, non-small-cell carcinoma (NSCLC), for which therapies often lead to unpredictable results.

"We are frequently surprised with the range of responses that our patients' non-small-cell carcinomas have. Some are very responsive to treatment, some metastasize early, and we have no way of sorting this out up front," said study lead author Dr. David Neil Hayes, assistant professor of medicine in the division of hematology/oncology in UNC's School of Medicine. To that end, Hayes and his colleagues used a relatively new technology, DNA microarray analysis, which allows researchers to identify a tumor's genetic pattern.

... more about:
»DNA »carcinoma »subtypes

"We found that among patients who have tumors that look similar under a microscope there are dramatically different gene expression patterns," Hayes said. "But what's more interesting is that we see evidence that these genetic patterns are associated with significant differences in tumor behavior, which could not be anticipated by any conventional testing method."

The tumor subtypes, named bronchioid, squamoid and magnoid, according to their genetic pattern, also correlated with clinically relevant events, such as stage-specific survival and metastatic pattern.

For example, bronchioid tumors were associated with the likelihood of improved survival in early-stage disease, while squamoid tumors were associated with better survival in advanced disease.

And although some early-stage bronchioid tumors appear less likely to spread to the brain, they also may be the same tumors that are least likely to respond to chemotherapy because they express many genes associated with resistance to common chemotherapy agents.

"While this is still very preliminary, we hope to take these gene expression patterns and attempt to define a very simple, reproducible system that will allow us to unravel the complex patterns of how the tumors progress and how they respond to therapy," Hayes said.

"If we can pigeonhole these tumors right from the start, then we can become much more rational in our decision making for treatment and our ability to tell patients what to anticipate in terms of their risk, likelihood of recurrence and response to therapy," Hayes said. "That's the goal."

The new study evaluated lung cancer DNA microarray data sets from the University of Michigan, Stanford University and the Dana-Farber Cancer Institute in Boston, Mass. A total of 231 microarrays, each with 2,553 genes were analyzed. Hayes and his colleagues noted that the three new subtypes were robust and could be found frequently. All were identified in each of the data sets.

L. H. Lang | EurekAlert!
Further information:
http://www.unc.edu

Further reports about: DNA carcinoma subtypes

More articles from Life Sciences:

nachricht Staying in Shape
16.08.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik

nachricht Chips, light and coding moves the front line in beating bacteria
16.08.2018 | Okinawa Institute of Science and Technology (OIST) Graduate University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Staying in Shape

16.08.2018 | Life Sciences

Diving robots find Antarctic seas exhale surprising amounts of carbon dioxide in winter

16.08.2018 | Earth Sciences

Protein droplets keep neurons at the ready and immune system in balance

16.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>