Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Role of protein in immune response may aid HIV research

01.08.2006
A family of proteins that serve as the body's first line of defense against bacterial infections may provide a lifeline for individuals with compromised immune systems, according to researchers at the Indiana University School of Medicine – Northwest.

In the July 28 issue of the Journal of Biological Chemistry, Roman Dziarski, Ph.D., and Dipika Gupta, Ph.D., propose that the proteins might be used to develop medications that could boost the body's impaired day-to-day response to bacteria in HIV/AIDS patients and others with compromised immune responses. The scientists announced discovery of the protein called PGLYRP – peptidoglycan recognition proteins – earlier this year.

Patients, such as those with HIV/AIDS, are susceptible to bacterial infections that are easily averted by people with healthy immune systems but are life-threatening to people with impaired systems.

Drs. Dziarski and Gupta, in their latest report, revealed many parts of the body produce these proteins, which fight disease-causing bacteria. These proteins appear to be the front line in defending the body from infection, mounting a defense long before the body's main immune system responds.

The IU School of Medicine – Northwest scientists report that various organs mount different defensive responses with PGLYRP when exposed to bacteria. The skin produces these proteins only when exposed to virulent or high numbers of bacteria.

In contrast, the liver, whose function is to continuously monitor the blood and fight acute infection, produces PGLYRP constantly. The researchers suggest that the liver's constant protein production may help fulfill the organ's preventative role as a blood filter.

Mary Hardin | EurekAlert!
Further information:
http://www.iupui.edu

More articles from Life Sciences:

nachricht Researchers target protein that protects bacteria's DNA 'recipes'
21.08.2018 | University of Rochester

nachricht Protein interaction helps Yersinia cause disease
21.08.2018 | Schwedischer Forschungsrat - The Swedish Research Council

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Air pollution leads to cardiovascular diseases

21.08.2018 | Ecology, The Environment and Conservation

Researchers target protein that protects bacteria's DNA 'recipes'

21.08.2018 | Life Sciences

A paper battery powered by bacteria

21.08.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>