The study was conducted jointly by NYU's Department of Chemistry and the Department of Radiology at the NYU School of Medicine. The study is part of a collaborative discussion group between these departments called Molecular Imaging and Contrast Agents (MICA). Contrast agents are chemical compounds that enhance the ability of medical imaging techniques, such as MRI, to discriminate between different tissue types. MICA includes Chemistry Professor James Canary, radiologist Dr. Edwin Wang, and assistant chemistry professor Kent Kirshenbaum. Assistance for the study was provided by the University of New Mexico's Department of Molecular Genetics and Microbiology at its Health Sciences Center.
The protein coats of viruses provide an attractive platform for tailoring the physical properties and functions of molecular assemblies because they contain a large number of chemically reactive groups organized in a very precise array. Other researchers have recently sought to enhance MRI capabilities through the use of similar large molecular assemblies by increasing the size, and therefore signal, of MRI contrast agents. They have also tried to use this terrain to facilitate "multi-modality," in which a set of imaging probes, such as those for both MR and optical imaging, are integrated.
The NYU researchers were able to show the attachment of a large number of gadolinium chelates--the chemical compound used in MRI contrast agents --on the surface of the viral particles. This resulted in the generation of a very intense signal when Wang imaged their samples in a clinical MRI scanner.
"Our work validates some hypotheses in the field of Magnetic Resonance Imaging contrast agents," explained Kirshenbaum, the study's corresponding author. "Previous studies have predicted that as you increase the particle size of an MR contrast agent, you should see it become more effective--as the particle takes longer to tumble in solution, it should become more capable of influencing the response of neighboring water molecules. Our study provides evidence that this effect works. Since the signal that radiologists observe in MRI scans is generated primarily from water molecules within the body, we potentially have the ability to get better contrast and clearer images that can distinguish between different tissue types."
While Kirshenbaum cautioned that many obstacles remain in using this process to enhance MRI for clinical applications, he said the results point to the potential of enhancing specific MRI capabilities.
"If a radiologist wants to design a versatile probe that can be used in a variety of different imaging protocols, a chemically modified virus particle now appears to be an attractive option for this type of sophisticated application," he noted. "For example, if we can decorate the particles so that they are recognized by specific receptors on cell surfaces, we may be able to use MRI to image tumors much smaller than can currently be seen."
James Devitt | EurekAlert!
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
Russian researchers together with their French colleagues discovered that a genuine feature of superconductors -- quantum Abrikosov vortices of supercurrent -- can also exist in an ordinary nonsuperconducting metal put into contact with a superconductor. The observation of these vortices provides direct evidence of induced quantum coherence. The pioneering experimental observation was supported by a first-ever numerical model that describes the induced vortices in finer detail.
These fundamental results, published in the journal Nature Communications, enable a better understanding and description of the processes occurring at the...
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
25.06.2018 | Physics and Astronomy
25.06.2018 | Earth Sciences
25.06.2018 | Power and Electrical Engineering