This diagram depicts how a protein called ATF2 constantly shuttles from the nucleus to the cytoplasm in cells, a mechanism that may play a crucial role in cancers ability to resist chemotherapy and radiation treatment and that also may be involved in Alzheimers and heart disease. ATF2 was previously believed to be confined to the nucleus of healthy cells, but researchers at Purdue University discovered that it actually shuttles between the nucleus and cytoplasm. The researchers used a novel imaging technique invented at Purdue to track the protein, learning that its shuttling is controlled by the presence of another protein in the nucleus and its attachment to that second protein. The findings could provide a new avenue for the development of innovative treatments for certain cancers and other conditions. (Purdue Department of Medicinal Chemistry and Molecular Pharmacology)
Researchers at Purdue University have discovered a molecular mechanism that may play a crucial role in cancer’s ability to resist chemotherapy and radiation treatment and that also may be involved in Alzheimer’s and heart disease.
The scientists, using an innovative imaging technique invented at Purdue, have learned that a protein previously believed to be confined to the nucleus of healthy cells actually shuttles between the nucleus and cytoplasm, the region of the cell surrounding the nucleus. Moreover, the protein’s shuttling is controlled by the presence of another protein in the nucleus and its attachment to that second protein.
"Our findings may provide a new avenue for the development of innovative treatments for certain cancers and other conditions," said Chang-Deng Hu, an assistant professor in Purdue’s Department of Medicinal Chemistry and Molecular Pharmacology and an investigator at the Walther Cancer Institute in Indianapolis.
Emil Venere | EurekAlert!
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