Synthetic biology experiment turns up a previously unrecognized gene-expression phenomenon
A high level of variation in the amount of green fluorescence protein in individual non-growing E. coli cells surprised synthetic biology researchers at Boston University and the University of California, San Diego
An experiment designed to show how a usually innocuous bacterium regulates the expression of an unnecessary gene for green color has turned up a previously unrecognized phenomenon that could partially explain a feature of bacterial pathogenicity.
In a paper published in the Feb. 16 issue of Nature, researchers at Boston University (BU) and the University of California, San Diego (UCSD) reported that computer modeling predicted the new phenomenon before they confirmed it in laboratory experiments. The group led by James J. Collins, a biomedical engineering professor at BU, and Jeff Hasty, a bioengineering professor at UCSD, reported that the rise and fall in the amount of green-fluorescence protein in computer modeling matched the pattern recorded in E. coli cells grown in various laboratory conditions.
Rex Graham | EurekAlert!
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