Researchers have produced the strongest evidence yet that mitochondria — the organelles that generate energy to power the cell — also monitor oxygen concentration in the cell. If oxygen slips below a critical threshold, the mitochondrial “sensor” triggers protective responses to promote survival.
Understanding how the cell senses and protects itself against hypoxia (low oxygen) has both important basic and clinical implications for biology and medicine, said one of the study’s senior authors, M. Celeste Simon, a Howard Hughes Medical Institute investigator at the University of Pennsylvania. “Oxygen is absolutely essential for life, so the biological mechanisms underlying response to low oxygen are central to the cell,” she said. “For example, during early development, the embryo exists in a naturally hypoxic environment until it is connected to the maternal cardiovascular system.
“In the adult, changes in oxygen levels occur during inflammation and atherosclerosis; and even transient oxygen starvation can have a profound impact on the brain,” said Simon. “For example, the well-known case of the late Terry Schiavo, in which a cardiac episode reduced her to a vegetative state, was the result of only brief oxygen starvation.”
Jim Keeley | EurekAlert!
UNH researchers create a more effective hydrogel for healing wounds
21.11.2018 | University of New Hampshire
Removing toxic mercury from contaminated water
21.11.2018 | Chalmers University of Technology
Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.
Electric diodes are essential electronic components that conduct electricity in one direction but prevent conduction in the opposite one. They are found at the...
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
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