Severely obese children have lipoprotein profiles that signal early risk of cardiovascular disease and the metabolic syndrome, according to a study presented at the American Heart Associations Sixth Annual Scientific Conference on Arteriosclerosis, Thrombosis and Vascular Biology.
"The message is urgent about the importance of prevention of cardiovascular disease in childhood. Lifestyle modification with appropriate diet and exercise can reduce cardiovascular risk in children," said lead author Daniel L. PreudHomme, M.D., associate professor of medicine at the Wright State University School of Medicine and director of the lipid clinic at The Childrens Medical Center, both in Dayton, Ohio.
Lipoproteins transport cholesterol throughout the body. Lipoprotein subclasses and the size of lipoprotein particles can be measured by a test that uses nuclear magnetic resonance (NMR) spectroscopy to provide a more detailed lipid profile than standard lipid panels.
Lipid abnormalities are part of a cluster of conditions comprising the metabolic syndrome. Metabolic syndrome is also closely associated with a generalized metabolic disorder called insulin resistance, in which the body cannot efficiently use insulin. People with the metabolic syndrome are at increased risk of coronary heart disease, stroke, peripheral vascular disease and type 2 diabetes.
The study found no gender differences for lipoprotein variables.
Carole Bullock | EurekAlert!
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