Researchers at Fox Chase Cancer Center in Philadelphia say looking for genes that have been turned off by cancer cells may become a reliable and noninvasive way to detect and monitor cancer in the kidney. The data were presented today at the 96th Annual Meeting of the American Association for Cancer Research in Anaheim, Calif.
Tumor-suppressor genes are part of the bodys natural defense against cancer. When inactivated--or "silenced"--they can no longer do their job, allowing cancer cells to grow. Cancer cells use a mechanism called hypermethylation to turn off the tumor-suppressor genes. "Finding these silenced genes is a good way to find cancer," said Essel A. Dulaimi, M.D., a postdoctoral fellow at Fox Chase. "Abnormal patterns of methylation can be detected in many cancers, including kidney cancer," she added. Early diagnosis of kidney cancer can lead to earlier treatment with a curative outcome.
Dulaimi and fellow Fox Chase researchers used a molecular DNA-based test to determine the presence or absence of methylation in a particular gene. Called methylation-specific polymerase chain reaction (PCR), the test can find one methylated gene among 100 unmethylated alleles (genes at the same site on a specific chromosome).
Colleen Kirsch | EurekAlert!
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences