Despite the well-characterized cellular basis of Parkinsons disease -- the degeneration of dopamine-production neurons -- the molecular mechanisms responsible for the neurodegeneration remain unknown. Part of the challenge is finding a model that can adequately mimic the loss of dopamine cells. In two papers published in PLoS Biology, Asa Abeliovich and colleagues make the case that a model based on mouse embryonic stem cells offers a promising platform for dissecting the disease mechanism of Parkinsons.
Working with these cells, the researchers created dopamine neurons deficient in DJ-1, a gene mutated in an inherited form of Parkinsons. They report that DJ-1-deficient cells -- and especially DJ-1-deficient dopamine neurons -- display heightened sensitivity to oxidative stress, caused by products of oxygen metabolism that react with and damage cellular components like proteins and DNA. In a second paper, they link DJ-1 dysfunction to the aggregation of alpha-synuclein, a hallmark of Parkinsons neuropathology.
Oxidative stress has long been associated with neuronal cell death and neurodegenerative diseases like Parkinsons. Proving a causal relationship between oxidative stress and neurodegeneration, however, requires establishing a molecular mechanism. These results support a link between oxidative damage and disease, and provide a tractable model for both studying the molecular mechanisms of neurodegenerative disease and screening potential neuroprotectant drugs. The authors are hoping to extend their work to human embryonic stem cells, but their work is limited by the availability of such cells under the current NIH guidelines.
Paul Ocampo | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
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On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
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