Researchers have developed a method for scanning the entire human genome to successfully map the location of key gene regulators, mutated forms of which are known to cause type 2 diabetes. The research marks the first time that human organs, in this case the pancreas and liver, have been analyzed in this way and opens the door to similar studies of other organ systems and diseases.
The work, published in the Feb. 27 issue of the journal Science, could lead to new approaches for developing medications and assessing a persons genetic risk to this and other conditions, says Richard Young, a scientist at Whitehead Institute for Biomedical Research and lead researcher on the project.
Key to understanding the relationship between genes and disease are gene regulators called transcription factors, proteins that bind to specific areas of the genome and act to switch genes on and off. To discover how a specific transcription factor might contribute to a particular disease, scientists must locate each point in the genome where the transcription factor adheres and identify the individual genes it controls. Using conventional tools, it might take a single scientist a lifetime to do this for just one transcription factor. Yet humans have over 1,000 transcription factors and dozens of these have been linked to diseases.
David Cameron | EurekAlert!
Sensory Perception Is Not a One-Way Street
17.10.2018 | Eberhard Karls Universität Tübingen
Sex or food? Decision-making in single-cell organisms
17.10.2018 | Max-Planck-Institut für chemische Ökologie
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
17.10.2018 | Event News
16.10.2018 | Event News
02.10.2018 | Event News
17.10.2018 | Trade Fair News
17.10.2018 | Life Sciences
17.10.2018 | Agricultural and Forestry Science