A group of researchers from The Scripps Research Institute (TSRI) has solved structures of a bacterial protein called pilin, which is required for infection by pathogens that cause human diseases like meningitis, gonorrhea, diarrheal diseases, pneumonia, and cholera.
In the latest issue of the journal Molecular Cell, the TSRI group reports two key structures of these pilins and discoveries about their assembly into fibrous "pili." Because a whole class of bacterial pathogens require the assembly of pilin into the hair-like pilus filaments on their surface in order for them to move around, attach to, and infect host cells, the authors believe that this research provides essential knowledge to help scientists develop novel antibiotics and vaccines against these deadly and emerging bacterial diseases.
This work directly focuses on two such pathogens--Pseudomonas aeruginosa, which causes severe lung infections in cystic fibrosis patients, AIDS patients, and other immunocompromised individuals, and Vibrio cholerae, which causes cholera, a potentially fatal diarrheal disease that primarily afflicts people in developing countries.
Jason Bardi | EurekAlert!
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