Dutch PhD student Cathelijne Kloks has discovered that the so-called Cold Shock domain of the human YB-1 protein looks like a bucket with two extra ears. These ears lead the DNA to the binding site on the protein and keep it there.
Kloks investigated the structure and function of one of the three domains of the human protein YB-1. This protein plays an important role in the production of new proteins. The central domain, the so-called Cold Shock domain, ensures the binding of the protein to the DNA in the process.
The researcher from the University of Nijmegen discovered that the domain looks like a bucket with a handle and two extra ears. The ears attach to the DNA and push it to the binding site on the YB-1. This binding site was found to be located precisely in between the two ears. This means that the ears can hold the DNA firmly in place whilst it is being bound to the protein. The function of the handle is not yet clear.
Nalinie Moerlie | alfa
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