The discovery was published in the advance online publication of Nature Medicine 15 June.
The team showed that a pro-inflammatory cytokine protein — tumor necrosis factor- á (TNF-á) — disrupts the localization of polycystin 2 (the product of a gene mutated in ADPKD) to the plasma membrane and primary cilia in kidney epithelial cells, thus promoting the formation of cysts.
“The interaction between TNF-á and polycystin in the development of cysts is complicated,” said Xiaogang Li, Ph.D., Senior Research Associate in the Rong Li Lab and first author on the paper. “We believe that this interaction could play a significant role in the transition from normal tubule development to the onset of Polycystic Kidney Disease (PKD) in individuals predisposed for the disease.”
Additionally, the team found that the drug etanercept, an inhibitor of TNF-á currently used to treat rheumatoid arthritis and a number of other conditions, prevents the formation of cysts in the kidneys of mice with ADPKD.
“This discovery is especially exciting because it not only provides insight about the origins of ADPKD, but it also points us toward a drug that we believe shows promise in preventing the development of cysts,” said Rong Li, Ph.D., Investigator and senior author on the publication. “Of course, additional research will be required to test these preliminary results in animal models, but the potential is interesting.”
Currently, no treatments are available to prevent or delay the onset of cysts in people living with PKD. Dialysis and kidney transplants are often required as the disease progresses.
Xiaogang Li received a grant from the PKD Foundation earlier this year. The award of $150,000 over two years supports his efforts to understand the origins of PKD. For more information about PKD or the PKD Foundation, visit www.PKDCure.org.
Additional contributing authors from the Stowers Institute include Sheng Xia, Ph.D., Postdoctoral Research Associate; and Teri Johnson, Ph.D., Managing Director - Histology Facility. Also contributing from the University of Kansas Medical Center are James Calvet, Ph.D., Professor; Darren Wallace, Ph.D., Research Assistant Professor; and Brenda Magenheimer, Research Associate, who are supported by an NIH-funded P50 PKD Center grant.
In addition to her appointment at the Stowers Institute, Rong Li also is a Professor in the Department of Molecular & Integrative Physiology at the University of Kansas Medical Center. Learn more about her work at www.stowers-institute.org/labs/RongLiLab.aspAbout the Stowers Institute
Marie Jennings | EurekAlert!
Hopkins researchers ID neurotransmitter that helps cancers progress
25.04.2019 | Johns Hopkins Medicine
Trigger region found for absence epileptic seizures
25.04.2019 | RIKEN
Flexible, organic and printed electronics conquer everyday life. The forecasts for growth promise increasing markets and opportunities for the industry. In Europe, top institutions and companies are engaged in research and further development of these technologies for tomorrow's markets and applications. However, access by SMEs is difficult. The European project SmartEEs - Smart Emerging Electronics Servicing works on the establishment of a European innovation network, which supports both the access to competences as well as the support of the enterprises with the assumption of innovations and the progress up to the commercialization.
It surrounds us and almost unconsciously accompanies us through everyday life - printed electronics. It starts with smart labels or RFID tags in clothing, we...
The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.
Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.
Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.
Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...
A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter
A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.
Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...
17.04.2019 | Event News
15.04.2019 | Event News
09.04.2019 | Event News
25.04.2019 | Materials Sciences
25.04.2019 | Earth Sciences
25.04.2019 | Life Sciences