Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Snake venoms share similar ingredients

20.12.2007
Venoms from different snake families may have many deadly ingredients in common, more than was previously thought. A study published in the online open access journal BMC Molecular Biology has unexpectedly discovered three-finger toxins in a subspecies of the Massasauga Rattlesnake, as well as evidence for a novel toxin genes resulting from gene fusion.

Susanta Pahari from National University of Singapore, Singapore (currently working at Sri Bhagawan Mahaveer Jain College, Bangalore, India) used venom glands from a rare rattlesnake that lives in arid and desert grasslands. Known as Desert Massasauga (Sistrurus catenatus edwardsii), this pitviper is a subspecies of the North American Massasauga Rattlesnake (Sistrurus catenatus).

Together with Stephen Mackessy from the University of Northern Colorado, USA and R. Manjunatha Kini from National University of Singapore, Singapore, Pahari constructed a cDNA library of the snake's venom gland and created 576 tagged sequences. A cocktail of recognized venom toxin sequences was detected in the library, but the venom also contained three-finger toxin-like transcripts, a family of poisons thought only to occur in another family of snakes (Elapidae). The team also spotted a novel toxin-like transcript generated by the fusion of two individual toxin genes, a mechanism not previously observed in toxin evolution. Toxin diversity is usually the result of gene duplication and subsequently neofunctionalization is achieved through several point mutations (called accelerated evolution) on the surface of the protein. Pahari says "In addition to gene duplication, exon shuffling or transcriptional splicing may also contribute to generating the diversity of toxins and toxin isoforms observed among snake venoms."

Previously, researchers identified venom compounds using protein chemistry or individual gene cloning methods. However, less abundant toxins were often missed. The library method has now revealed new toxin genes and even new families of toxins. Taking low abundance toxins into consideration shows advanced snakes' venoms actually have a greater similarity than previously recognized.

... more about:
»Toxin »venom

Snake venoms are complex mixtures of pharmacologically active proteins and peptides. Treating snake venom victims can be complicated because of the variation between venoms even within snake families. Kini says "Such a diversity of toxins provides a gold mine of bioactive polypeptides, which could aid the development of novel therapeutic agents."

Charlotte Webber | alfa
Further information:
http://www.biomedcentral.com/bmcmolbiol/

Further reports about: Toxin venom

More articles from Life Sciences:

nachricht New eDNA technology used to quickly assess coral reefs
18.04.2019 | University of Hawaii at Manoa

nachricht New automated biological-sample analysis systems to accelerate disease detection
18.04.2019 | Polytechnique Montréal

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>