Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Map of substrate-kinase interactions may lead to more effective cancer drugs

28.03.2012
Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help drugmakers close more routes and develop better drugs.

Kinase enzymes deliver phosphates to cell proteins in a process called phosphorylation, switching a cellular function on or off. Irregularities in phosphorylation can lead to uncontrolled cell growth and are a hallmark of cancer.

Many successful cancer drugs are kinase inhibitors, which block the ability of a kinase to bind with a particular protein on the cell, stopping phosphorylation and the creation of cancer cells.

W. Andy Tao, a Purdue associate professor of biochemistry and member of the Purdue University Center for Cancer Research, said that in later stages of cancers, kinase-inhibiting drugs are ineffective because the kinases adapt, finding new protein targets and forming new cancer cells. He believes that creating maps of all the potential routes for cancer cell formation is a key to developing better cancer drugs.

"I would say that 99 percent of these drugs are effective for a few months in late-state cancers, and then the cancers develop resistance," said Tao, whose findings were published online early in the Proceedings of the National Academy of Sciences. "In the beginning, the cell cannot adjust and it dies. In later stages, the cells find a way. Cancer cells find a way to survive. You block one pathway, and they find another."

The kinase-protein maps Tao is creating identify kinases and the direct protein targets they phosphorylate. His method weeds out other proteins that are not direct targets, but are later phosphorylated as part of a cascade of reactions that begins when direct target proteins are phosphorylated.

Tao compared cells with and without kinases. The phosphoproteins present only when a kinase was present were considered possible targets. Further, the proteins were dephosphorylated, meaning the phosphate groups that had been added by kinases were removed.

The kinase was then re-introduced, and those proteins that accepted phosphate groups from the kinase were deemed direct targets of that kinase. With that information, drugmakers could tailor kinase-inhibiting drugs to ensure that the drug would stop kinases from reaching all potential targets, making the drugs more effective.

"If you understand the network, you can block all the pathways to cure the cancer," Tao said.
Tao's research findings focused on the SYK kinase, which is involved in leukemia and breast cancers. He plans to study other kinases, as well as mutated kinases, to understand whether they have different protein targets.

Tao collaborated with Robert Geahlen, a professor in medicinal chemistry and molecular pharmacology at Purdue. The National Institutes of Health funded the research.

Writer: Brian Wallheimer, 765-496-2050, bwallhei@purdue.edu
Source: Andy Tao, 765-494-9605, taow@purdue.edu
Ag Communications: (765) 494-2722;
Keith Robinson, robins89@purdue.edu
Agriculture News Page

Brian Wallheimer | EurekAlert!
Further information:
http://www.purdue.edu

More articles from Life Sciences:

nachricht AI-driven single blood cell classification: New method to support physicians in leukemia diagnostics
13.11.2019 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Small RNAs link immune system and brain cells
13.11.2019 | Goethe-Universität Frankfurt am Main

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New Pitt research finds carbon nanotubes show a love/hate relationship with water

Carbon nanotubes (CNTs) are valuable for a wide variety of applications. Made of graphene sheets rolled into tubes 10,000 times smaller than a human hair, CNTs have an exceptional strength-to-mass ratio and excellent thermal and electrical properties. These features make them ideal for a range of applications, including supercapacitors, interconnects, adhesives, particle trapping and structural color.

New research reveals even more potential for CNTs: as a coating, they can both repel and hold water in place, a useful property for applications like printing,...

Im Focus: Magnets for the second dimension

If you've ever tried to put several really strong, small cube magnets right next to each other on a magnetic board, you'll know that you just can't do it. What happens is that the magnets always arrange themselves in a column sticking out vertically from the magnetic board. Moreover, it's almost impossible to join several rows of these magnets together to form a flat surface. That's because magnets are dipolar. Equal poles repel each other, with the north pole of one magnet always attaching itself to the south pole of another and vice versa. This explains why they form a column with all the magnets aligned the same way.

Now, scientists at ETH Zurich have managed to create magnetic building blocks in the shape of cubes that - for the first time ever - can be joined together to...

Im Focus: A new quantum data classification protocol brings us nearer to a future 'quantum internet'

The algorithm represents a first step in the automated learning of quantum information networks

Quantum-based communication and computation technologies promise unprecedented applications, such as unconditionally secure communications, ultra-precise...

Im Focus: Distorted Atoms

In two experiments performed at the free-electron laser FLASH in Hamburg a cooperation led by physicists from the Heidelberg Max Planck Institute for Nuclear physics (MPIK) demonstrated strongly-driven nonlinear interaction of ultrashort extreme-ultraviolet (XUV) laser pulses with atoms and ions. The powerful excitation of an electron pair in helium was found to compete with the ultrafast decay, which temporarily may even lead to population inversion. Resonant transitions in doubly charged neon ions were shifted in energy, and observed by XUV-XUV pump-probe transient absorption spectroscopy.

An international team led by physicists from the MPIK reports on new results for efficient two-electron excitations in helium driven by strong and ultrashort...

Im Focus: A Memory Effect at Single-Atom Level

An international research group has observed new quantum properties on an artificial giant atom and has now published its results in the high-ranking journal Nature Physics. The quantum system under investigation apparently has a memory - a new finding that could be used to build a quantum computer.

The research group, consisting of German, Swedish and Indian scientists, has investigated an artificial quantum system and found new properties.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

High entropy alloys for hot turbines and tireless metal-forming presses

05.11.2019 | Event News

Smart lasers open up new applications and are the “tool of choice” in digitalization

30.10.2019 | Event News

International Symposium on Functional Materials for Electrolysis, Fuel Cells and Metal-Air Batteries

02.10.2019 | Event News

 
Latest News

Necessity is the mother of invention: Fraunhofer WKI tests utilization of low-value hardwood for wood fiberboard

13.11.2019 | Materials Sciences

With Mars methane mystery unsolved, curiosity serves scientists a new one: Oxygen

13.11.2019 | Physics and Astronomy

AI-driven single blood cell classification: New method to support physicians in leukemia diagnostics

13.11.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>