Cells lacking PRC2 (top) or cells containing an altered histone that can no longer be tagged (bottom) show the same effect: a gene that normally should be shut down, is activated (red signal). As opposed to the surrounding wild type cells marked with green.
Figure: Ana R. Pengelly/ Copyright: MPI of Biochemistry
Using the model organism Drosophila - the fruit fly - the scientists now generated animals with cells expressing an altered histone protein to which PRC2 can no longer add the tag. These cells cannot keep genes inactive anymore and many cell fate decisions go awry, exactly like in cells that lack the PRC2 enzyme. “This observation demonstrates that the business end is the tag on the histone and not on some other protein” says Ana Pengelly, the PhD student who conducted the experiments.
Her colleague Omer Copur adds: “The approach we used permits us to now also investigate the function of other tags on histone proteins that have a different chemical nature.” The insight gained from the work on PRC2 provides a strong impetus to figure how this tag alters the beads-on-a-string structure of genes and thereby controls gene activity.
Anja Konschak | Max-Planck-Institut
Fish recognize their prey by electric colors
13.11.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
The dawn of a new era for genebanks - molecular characterisation of an entire genebank collection
13.11.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
13.11.2018 | Life Sciences
13.11.2018 | Life Sciences
13.11.2018 | Awards Funding