Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Funding of Collaborative Research Center developing nanomaterials for cancer immunotherapy extended

28.06.2017

Focus on the development of drug carriers from polymer chemicals for use in biological systems

The German Research Foundation (DFG) has agreed to fund the Mainz-based Collaborative Research Center (CRC) 1066 "Nanodimensional Polymer Therapeutics for Tumor Therapy" involved in the development of nanomaterials for cancer immunotherapy for another four years to the end of June 2021.


CRC 1066 logo

© CRC 1066

This extension confirms Mainz as a major research hub in this field that requires input from both chemistry and biomedicine alike. Contributing to CRC 1066 are the Chemistry, Pharmaceutical Sciences, and Physics institutes at Johannes Gutenberg University Mainz (JGU) together with the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) in Mainz. The German Research Foundation will provide nearly EUR 13 million in financing over the next four years.

CRC 1066 is pursuing the development of new, multi-functional nanoparticle drug carriers that can be employed in the immunotherapy of malignant melanomas. "Chemists, biologists, and physicians work together extensively here in three complementary and thus closely integrated areas," explained CRC Coordinator Professor Rudolf Zentel of the Institute of Organic Chemistry at Mainz University.

The objective is to use new nano-sized drug carriers to create targeted immune responses that can be used for treatment purposes. This can only be achieved by means of close interdisciplinary collaboration between polymer chemists, physical chemists, and (cancer) immunologists, i.e., three disciplines which traditionally have vastly different methodologies and scientific working methods.

"Over the past three years, we have managed to put in place an excellent foundation for our work on which we now mean to build. The main difficulty at first was learning to understand the various 'languages' used in the other scientific fields," Professor Katharina Landfester, Director of the MPI-P, pointed out. Professor Stephan Grabbe of the Mainz University Medical Center added:

"Our findings are being published in internationally eminent journals and we are very proud of the fact that we have recently seen the first fruits of our research being employed for the purpose of clinical trials in patients."

In the second funding period, the CRC will retain its current structure whereby it undertakes primarily polymer-chemical synthesis projects, translational-application oriented projects as well as analytical interdisciplinary projects.

At the same time, however, its focus will be more on the actual application of drug carriers created using polymer-chemical processes in biological systems rather than on the polymer synthesis method itself. The fully established collaboration between chemists and immunologists means that most individual projects can be jointly run by polymer chemists and immunologists.

The interdisciplinary nature of the CRC 1066 is reflected by the membership of its board. The board is composed of coordinator Professor Rudolf Zentel of Mainz University and the two vice coordinators Professor Stephan Grabbe of the Department of Dermatology of the Mainz University Medical Center and Professor Katharina Landfester of the Max Planck Institute for Polymer Research. Other members of the board are Professor Detlef Schuppan of the Department of Internal Medicine I of the Mainz University Medical Center and, as the representative for young researchers, Dr. Mathias Barz of the JGU Institute of Organic Chemistry.

Ill.:
http://www.uni-mainz.de/bilder_presse/09_orgchemie_sfb1066_II.jpg
CRC 1066 logo
© CRC 1066

Further information:
Professor Dr. Rudolf Zentel
Institute of Organic Chemistry
Johannes Gutenberg University Mainz (JGU)
55099 Mainz, GERMANY
phone +49 6131 39-20361
fax +49 6131 39-24778
e-mail: zentel@uni-mainz.de
http://www.ak-zentel.chemie.uni-mainz.de/eng/

Professor Dr. Stephan Grabbe
Department of Dermatology
Mainz University Medical Center
55131 Mainz, GERMANY
phone +49 6131 17-4412
e-mail: stephan.grabbe@unimedizin-mainz.de
http://www.hautklinik-mainz.de/dermatology/scientists/overview.html?L=1

Professor Dr. Katharina Landfester
Max Planck Institute for Polymer Research (MPI-P)
55128 Mainz, GERMANY
phone +49 6131 379-171
e-mail: landfester@mpip-mainz.mpg.de
http://www.mpip-mainz.mpg.de/physical_chem_of_polymers

Related links:
* http://www.crc1066.uni-mainz.de/ – Collaborative Research Center 1066: Nanodimensional polymer therapeutics for tumor therapy
* http://www.uni-mainz.de/presse/16451_ENG_HTML.php – press release "Johannes Gutenberg University Mainz obtains new Collaborative Research Center on 'Nanodimensional polymer therapeutics for tumor therapy'" (31 May 2013)

Petra Giegerich | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>