Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

EVMS researchers identify potential target for treatment of obesity-related diseases

15.04.2010
EVMS scientists recently presented preliminary research findings that identify a specific gene as a potential new target for treating obesity-related diseases.

Two research studies funded by grants from the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH) examined the role of a gene called STAT4 in the development of Type 2 diabetes and other obesity-related cardiovascular diseases. The research was presented at the 2010 annual meeting of the American Heart Association’s Council on Atherosclerosis, Thrombosis and Vascular Biology.

“We’ve known for some time that STAT4 is a ‘gene switch,’ meaning it is one of the genes that regulates or ‘turns on’ immune cells. But, our preliminary findings indicate that STAT4 is also involved in the metabolic process,” says Anca D. Dobrian, PhD, assistant professor of physiology and lead author of one of the studies.

“Specifically, we’ve found that STAT4 appears to be involved in insulin resistance as well as the development of atherosclerosis,” adds Elena V. Galkina, PhD, assistant professor of microbiology and molecular cell biology. “Assuming these results in rodent-models hold true for humans, STAT4 offers a potentially attractive target for therapy.”

Early findings in these studies indicate that insulin resistance and atherosclerosis, a condition characterized by the thickening of artery walls due to fatty plaque deposits, occur in conjunction with elevated levels of STAT4.

The researchers learned that eliminating STAT4 in rodent models reduced the development of atherosclerosis. Similarly, eliminating STAT4 in rodent models given a high-fat diet revealed that while the rodents gained the same amount of weight as rodents with the gene, they did not develop insulin resistance — which is a risk factor for Type 2 diabetes and other heart problems.

“Basically,” says Jerry Nadler, MD, director of the EVMS Strelitz Diabetes Center, chair of internal medicine and co-author on both papers, “it appears that excess STAT4 is working in hyper-drive, leading to inflamed fat which can produce these problems. This is significant because prior to this study, no one knew that STAT4 was involved in insulin resistance or atherosclerosis.”

These findings lay the groundwork for pivotal follow-up studies on the relationship between metabolic responses and immunity.

“Now that we know STAT4 is a factor,” Dr. Dobrian says, “the next steps will be to work on better understanding the mechanisms behind it with the ultimate goal of developing a drug that blocks or inhibits STAT4, without eliminating it entirely.“

The doctors say that STAT 4 is a particularly attractive target for treatment because it exists in only a few cell types throughout the body, and, therefore, any drug that regulates the gene’s expression to maintain normal levels is less likely to cause other side effects.

“This is an important first step in identifying a new target for treatment of the most urgent health problem throughout not only the United States, but much of the developed world,” Dr. Galkina says. “If we can develop a way to reduce the health problems associated with obesity, we can save a lot of people.”

Drs. Galkina and Dobrian also are funded by research grants from the American Heart Association.

About EVMS:
Eastern Virginia Medical School was established in 1973 to provide better health care options for Hampton Roads. The EVMS focus on teaching, discovering and caring ensures high-quality medical education for aspiring physicians and health professionals; the advancement of innovative medical research; and high-quality, patient-centered care.

Jina Gaines | EurekAlert!
Further information:
http://www.evms.edu

More articles from Life Sciences:

nachricht Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>