Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New beta-blocker to offer hope to heart and lung sufferers

29.08.2008
Researchers at The University of Nottingham have been awarded £2.8 million by the Wellcome Trust to develop a new drug that could ease the suffering of hundreds of thousands of heart disease patients who are unable to take beta-blockers.

In the UK, 2.6 million people suffer from heart disease and most are able to have their symptoms effectively managed with the prescription of beta-blocker drugs which stop adrenaline from making the heart work too hard.

However, a major side effect of beta-blockers is that they make the symptoms of asthma and other breathing problems worse, so that around 300,000 patients in the UK who also suffer from respiratory conditions are prevented from taking them.

Now, a team of scientists from the University’s Schools of Biomedical Sciences and Pharmacy will use the Wellcome Trust’s funding, made under the Seeding Drug Discovery initiative, to conduct a three-year study to develop a modified type of beta-blocker that will treat heart disease and angina without exacerbating any underlying respiratory problems..

If successful, the new drug could become the general medicine of choice for all heart patients because its targeted action will lead to a significant reduction in overall side effects.

Even the best currently available beta-blockers are poor at discriminating between the heart and lungs, causing the muscles in the lungs to tighten and making breathing more difficult in some patients who have a pre-existing lung complaint.

In patients suffering from asthma, in which environmental factors cause muscle contractions leading to a narrowing of the airway, taking these medicines can trigger an attack or, even if tolerated enough to be taken regularly, can stop other asthma drugs from working.

Doctors are also extremely wary in prescribing beta-blockers for patients suffering from heart disease and chronic obstructive pulmonary disease (COPD), a progressive condition which causes the destruction of lung tissue and increased mucus production, because any reduction in respiratory function that may be caused by the drugs could have a major impact on symptoms.

The Nottingham scientists have already developed a molecule that is much more effective at discriminating between the heart and lungs than current drugs. The funding will allow them to carry out further studies to improve the molecule to ensure that it is able to target the heart cells more effectively — therefore directing the therapeutic effect only to the heart and not the lungs. The aim is that the resulting drug will be long-lasting and could be taken orally.

Leading the research, Dr Jill Baker from the School of Biomedical Sciences said: “Once developed, this molecule will cause much less wheezing and shortness of breath and should be able to be given safely to the hundreds of thousands of patients with both heart and lung diseases. Furthermore, because it will have so few side effects, it has the potential to become the beta-blocker of choice for all heart patients.”

Dr Ted Bianco, Director of Technology Transfer at the Wellcome Trust, said: “We know that beta-blockers save lives in patients with heart disease, so making them safe for those unlucky enough to have a respiratory disorder as well is a clinical imperative. I applaud Jill Baker for questioning why beta-blockers should remain contraindicated for so many of her patients, and being stirred to correct this with an incisive programme of work. In the best traditions of medical research, this endeavour was born out of a problem encountered at the sharp end of clinical practice.”

Emma Thorne | alfa
Further information:
http://www.nottingham.ac.uk
http://www.wellcome.ac.uk

More articles from Life Sciences:

nachricht New eDNA technology used to quickly assess coral reefs
18.04.2019 | University of Hawaii at Manoa

nachricht New automated biological-sample analysis systems to accelerate disease detection
18.04.2019 | Polytechnique Montréal

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>