In chemistry, a reaction is spontaneous when it does not need the addition of an external energy input. How much energy is released in a reaction is dictated by the laws of thermodynamics. In the case of the spontaneous reactions that occur in the human body this is often not enough to power medical implants. Now, scientists at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international team of researchers, found a way to boost the energy output by storing and bundling the energy of many spontaneous enzyme reactions. The work is published in the journal Nature Communications.
Chemical reactions in which electrons are released can be used to generate electricity. In order to power future medical implants, biofuel cells are being developed, where enzymes, derived from living organisms, are employed to liberate electrons, for instance during the oxidation of sugar molecules. An important general problem is that the energy and voltage of the electrons that can be generated in a biofuel cell is rather small.
While it is easy in a household device to connect several batteries in series to boost the voltage, this is not possible in the human body, as each biofuel cell is necessarily immersed in the same fluid at the same electrical potential so that voltages cannot be added up. This means that biofuel cells can presently in most of the cases only generate much less than 1 Volt, which severely limits practical applications.
This is not only a matter of engineering, but the fundamental laws of thermodynamics also put limitations on the energy that can be released in the enzymatic reactions. The challenge is therefore to develop new approaches for biofuel cells that can circumvent these constraints.
Researchers from the University of Bordeaux, the French CNRS, the University of Stuttgart and the Max Planck Institute for Intelligent Systems (MPI-IS) have now found a clever way to overcome the restrictions imposed by thermodynamics.
They managed to temporarily store the electrons released when glucose is oxidized and to use some of this energy to autonomously boost the voltage of the remaining electrons. “No outside power is needed”, says Emmanuel Suraniti, postdoctoral fellow at the MPI-IS and first author of the study that is published in Nature Communications.
The principle of operation is very general and relies in storing the energy of the electrons temporarily in an electromagnetic field. To achieve this, a small electronic circuit – powered by the chemical reaction itself – is integrated into the biofuel cell in order to harvest the electricity and boost the voltage. Thus, the concept makes it possible to turn simple biomolecules into high-energy fuels.
“Converting the starting compounds into electrons of high energy via the biofuel cell opens up completely new possibilities to power electronics and to synthesize important chemicals”, says Peer Fischer, who heads the Micro, Nano and Molecular Systems lab at the Max Planck Institute for Intelligent Systems and who is a Professor of Physical Chemistry at the University of Stuttgart. “It is now possible to use the oxidation of abundant low-energy molecules to synthesize precious molecules that need higher energies to form, which is a completely new concept.”
Apart from biofuel cells that generate useful voltages, the researchers envision reactions inside the body where the oxidation of glucose drives the synthesis of large drug molecules – something that thermodynamics would otherwise not allow, but which becomes possible in what may well be a first demonstration of the direct integration of electronics during a chemical reaction.
The full scientific paper can be found here:
“Uphill production of dihydrogen by enzymatic oxidation of glucose without an external energy source”, Emmanuel Suraniti, Pascal Merzeau, Jérôme Roche, Sébastien Gounel, Andrew G. Mark, Peer Fischer, Nicolas Mano, Alexander Kuhn, Nature Communications 9, 3229 (2018).
Prof. Dr. Peer Fischer heads the Micro, Nano and Molecular Systems Lab at the Max Planck Institute for Intelligent Systems in Stuttgart and he is a Professor of Physical Chemistry at the University of Stuttgart.
Fischer received a BSc. degree in Physics from Imperial College London and a Ph.D. from the University of Cambridge. He was a visiting scientist at the European Laboratory for Nonlinear Spectroscopy in Florence (LENS) and a NATO Postdoctoral Fellow at Cornell University, before joining the Rowland Institute at Harvard University. At Harvard he held a Rowland Junior Research Fellowship and directed an interdisciplinary research lab for five years. In 2011 he moved his lab to the Max-Planck-Institute for Intelligent Systems in Stuttgart, where he is an Independent Group Leader.
Peer Fischer is a member of the Max Planck – Ecole Polytechnique Fédérale de Lausanne (EPFL) Center for Molecular Nanoscience and Technology as well as of the research network on Learning Systems with ETH Zürich. In 2009 he received a Fraunhofer Attract award and in 2011 he was awarded an ERC starting grant. In 2016, he received the World Technology Award, an award which was also won by Elon Musk. It is awarded for "innovative work with most likely long-term significance" for humanity. The category in which Fischer won: "IT Hardware". In 2018, Fischer was awarded an ERC Advanced Grant.
At the Max Planck Institute for Intelligent Systems we aim to understand the principles of Perception, Action and Learning in Intelligent Systems. The Max-Planck-Institute for Intelligent Systems is located in two cities: Stuttgart and Tübingen. Research at the Stuttgart site of the Max Planck Institute for Intelligent Systems covers small-scale robotics, self-organization, haptic perception, bio-inspired systems, medical robotics, and physical intelligence. The Tübingen site of the institute concentrates on machine learning, computer vision, robotics, control, and the theory of intelligence.
The MPI-IS is one of 84 Max Planck Institutes and facilities that make up the Max Planck Society, Germany's most successful research organization. Since its establishment in 1948, no fewer than 18 Nobel laureates have emerged from the ranks of its scientists, putting it on a par with the best and most prestigious research institutions worldwide. All Institutes conduct basic research in the service of the general public in the natural sciences, life sciences, social sciences, and the humanities. Max Planck Institutes focus on research fields that are particularly innovative, or that are especially demanding in terms of funding or time requirements. And their research spectrum is continually evolving: new institutes are established to find answers to seminal, forward-looking scientific questions, while others are closed when, for example, their research field has been widely established at universities. This continuous renewal preserves the scope the Max Planck Society needs to react quickly to pioneering scientific developments.
Linda Behringer | Max-Planck-Institut für Intelligente Systeme
Elusive compounds of greenhouse gas isolated by Warwick chemists
18.09.2019 | University of Warwick
Study gives clues to the origin of Huntington's disease, and a new way to find drugs
18.09.2019 | Rockefeller University
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.
At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.
Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...
Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
10.09.2019 | Event News
04.09.2019 | Event News
29.08.2019 | Event News
18.09.2019 | Innovative Products
18.09.2019 | Physics and Astronomy
18.09.2019 | Materials Sciences