Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Curt Meyer Memorial Prize for German Cancer Researchers Dr. Stephan Mathas and Dr. Martin Janz

07.07.2008
Cancer researchers Dr. Martin Janz and Dr. Stephan Mathas of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and the Charité - University Medicine Berlin, Germany, have been honored with the Curt Meyer Memorial Prize for their research on Hodgkin's lymphoma.

They received the prize, worth 10,000 euros, on July 4, 2008 in Berlin for their findings published in Nature Immunology* from Professor Peter Schlag, president of the Berlin Cancer Society (Charité, MDC). Hodgkin's lymphoma, a common form of cancer of the lymphatic system, originates from white blood cells (B cells), which alter their phenotype completely and thus lose all characteristics of a B cell.

Dr. Janz and Dr. Mathas succeeded in decoding the camouflage mechanisms of B cells. Based on these findings, cancer researchers hope that therapy strategies can be developed that will lead to an inhibition of cell growth or to apoptosis of the Hodgkin cells.

The phenotype of Hodgkin lymphoma cells is a riddle that has puzzled pathologists for years. It was not until 1994, some 160 years after the disease was first described by the British physician Sir Thomas Hodgkin (1832), that - using molecular biological methods - scientists discovered that the lymphoma bearing his name originates from the white blood cells, the B cells.

In their article, Dr. Janz and Dr. Mathas of the research group of Professor Bernd Dörken (MDC/Charité) were able to show that several molecular defects in the B cells are responsible for the unique phenotype of the disease. First, in Hodgkin/Reed-Sternberg cells which have evolved from the B cells, the genetic program that steers the maturation of the B cells and maintains their identity is perturbed. One of the main regulators of this program, E2A, is inhibited in Hodgkin lymphoma cells by two antagonists, Id2 and ABF-1. The researchers showed that this mechanism inhibits the gene expression pattern of B cells. Moreover, through the inhibition of E2A in Hodgkin lymphoma cells, genes are switched on that are not typical for B cell development.

Since 1988, the Curt Meyer Memorial Prize has been awarded annually by the Berlin Cancer Society to young scientists from Berlin for outstanding publications in the field of clinical and experimental oncology. The prize is named after Dr. Curt Meyer, a physician and health official of the Berlin Senate who was born in Herleshausen/Thuringia in 1891. In 1944, he was deported to Auschwitz where he as prisoner took care of fellow detainees suffering from epidemic disease. He survived the concentration camp and after the war dedicated himself to public health, including the care of cancer patients. He was the founder of several medical societies, including the Berlin State Committee against Cancer out of which the Berlin Cancer Society has evolved. Curt Meyer died in 1984 at the age of 93.

*Intrinsic inhibition of E2A by ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Stephan Mathas1,2*, Martin Janz1,2*, Franziska Hummel2, Michael Hummel3, Brigitte Wollert-Wulf2, Simone Lusatis2 , Ioannis Anagnosto-poulos3, Andreas Lietz2, Mikael Sigvardsson4, Franziska Jundt1,2, Korinna Jöhrens3, Kurt Bommert2, Harald Stein3 and Bernd Dörken1,2

1Max Delbrück Center for Molecular Medicine, Robert-Rossle-Str. 10, 13125 Berlin; 2Hematology, Oncology and Tumorimmunology, Charite, Medical University Berlin, Campus Virchow-Klinikum, Campus Berlin-Buch, Augustenburger Platz 1, 13353 Berlin; 3Institute for Pathology, Charite, Medical University Berlin, Campus Benjamin Franklin, 12200 Berlin; 4Department for Hematopoietic Stemcell Biology, Stemcell Center, Lund University, S221 84 Lund, Sweden

*These authors contributed equally to this work
Barbara Bachtler
Press and Public Affairs
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Robert-Rössle-Straße 10; 13125 Berlin; Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de

Barbara Bachtler | idw
Further information:
http://www.mdc-berlin.de/
http://www.mdc-berlin.de/en/news
http://www.krebsgesellschaft.de/wub_curt_meyer_gedaechtnispreis,27797.html

More articles from Awards Funding:

nachricht Advanced Grant for Grain Boundary Phase Transformations
06.08.2018 | Max-Planck-Institut für Eisenforschung GmbH

nachricht Driving on bark, building with nutshells
02.08.2018 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

'Building up' stretchable electronics to be as multipurpose as your smartphone

14.08.2018 | Information Technology

During HIV infection, antibody can block B cells from fighting pathogens

14.08.2018 | Life Sciences

First study on physical properties of giant cancer cells may inform new treatments

14.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>