Prediction of RNA Pseudoknots Using Heuristic Modeling with Mapping and Sequential Folding
The method finds the minimum free energy in the context of the biological folding direction (5’ to 3’) of RNA sequences.
It also identifies information about the flexibility of the RNA. Mapping methods are used to build and analyze the folded structure and add important 3D structural considerations.
The model suggests that many biological RNA molecules are optimized by natural selection to fold correctly in the natural context and that stable intermediate RNA secondary structure can persist that anticipates pseudoknot formation.
The model will be published in the online, open-access journal PLoS ONE on September 19.
Media Contact
More Information:
http://www.plosone.org/doi/pone.0000905All latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Newest articles
After 25 years, researchers uncover genetic cause of rare neurological disease
Some families call it a trial of faith. Others just call it a curse. The progressive neurological disease known as spinocerebellar ataxia 4 (SCA4) is a rare condition, but its…
Lower dose of mpox vaccine is safe
… and generates six-week antibody response equivalent to standard regimen. Study highlights need for defined markers of mpox immunity to inform public health use. A dose-sparing intradermal mpox vaccination regimen…
Efficient, sustainable and cost-effective hybrid energy storage system for modern power grids
EU project HyFlow: Over three years of research, the consortium of the EU project HyFlow has successfully developed a highly efficient, sustainable, and cost-effective hybrid energy storage system (HESS) that…