A new brake on cellular energy production discovered

Mitochondria release energy through a process known as cellular respiration – a chemical process inside each mitochondrion that results in the production of the cell's energy currency, the molecule ATP.

As important parts of the respiratory chain are encoded by mitochrondrial DNA, mtDNA, the cell can adapt its energy production to varying needs by increasing or reducing the expression of mtDNA. However, very little is known about how this process is regulated.

Two research teams at Karolinska Institutet, led by Claes Gustafsson and Nils-Göran Larsson respectively, have now made an important breakthrough by discovering an entirely new mitochondrial factor, MTERF3. This new factor inhibits the expression of mtDNA and can thus slow down the cell's energy production.

The discovery, which is published in the journal Cell, may in future lead to completely new ways of treating various diseases. Impaired mitochondrial function gives rise to a cellular energy crisis and probably plays an important role in a number of common diseases such as diabetes, heart failure and Parkinson’s disease, as well as in normal ageing.

Publication:
MTERF3 is a negative regulator of mammalian mtDNA transcription
Chan Bae Park, Jorge Asin-Cayuela, Yonhong Shi, Mina Pellegrini, Martina Gaspari, Rolf Wibom, Kjell Hultenby, Hediye Erdjment-Bromage, Paul Tempst, Maria Falkenberg, Claes M Gustafsson, Nils-Göran Larsson.

Cell, 27 July 2007