Scientists of the Biophysical Engineering Group of the University of Twente in The Netherlands have developed an ultrasensitive sensor that can be used in a handheld device to, within minutes, detect various viruses and measure their concentration. The sensor could be used to quickly screen people at hospitals, airports and emergency clinics to control outbreaks of diseases such as SARS and the bird flu. All it would take is a tiny sample of saliva, blood, or other body fluid. Dr. Aurel Ymeti and others present their results in February’s issue of Nano Letters. They already caught the attention of MIT’s Technology Review and the Materials Science and Nanotechnology section of Nature.com.
Monochromatic light from a laser source is coupled to a channel waveguide and is guided into four parallel channels. These four channels include one reference channel (4) and three measuring channels (1-3) that are used to monitor different viruses by coating the channels with appropriate antibodies. Upon exiting from these four waveguide channels, the light interferes on a screen generating an interference pattern. Specific virus binding to the antibody coated waveguide surface causes a corresponding phase change that is measured as a change in the interference pattern. Analysis of the interference pattern thus yields information on the amount of bound virus particles on different channels.
The essential innovation in the technique reported in this paper is the combining of an integrated optics interferometric sensor with antibody-antigen recognition approaches to yield a very sensitive, very rapid test for virus detection. The technology is amenable to miniaturization and mass-production, and thus has significant potential to be developed into a handheld, point-of-care device.
The attention this sensor is currently achieving in the international scientific and nanotechnology community can be understood in the light of recent serious virus outbreaks such as SARS and H5N1 bird flu virus. Future viral outbreaks are a major threat to the societal and economic development throughout the world. Therefore a rapid, sensitive, and easy-to-use test for viral infections is essential to prevent and to control such viral pandemics. Furthermore, a compact, portable device is potentially very useful in remote or developing regions without easy access to sophisticated laboratory facilities.
The technique is better than traditional methods such as PCR (polymerase chain reaction) because of its speed and ease of use without compromising sensitivity. In principle, with a device such as this, minimal pre-processing of samples is required, and one could imagine having several different, interchangeable, detection modules for rapid detection. It’s also possible to consider configuring the device to detect multiple analytes.
This sensor device is developed during the PhD project of Aurel Ymeti, financed by the STW Dutch Technology Foundation, in collaboration with several companies including Paradocs Group BV, bioMériex BV, and LioniX BV. The research is part of two research institutes within the University of Twente: MESA+ Institute for Nanotechnology and BMTI Institute for BioMedical Technology. A commercial prototype of this sensor is being developed by a Dutch company.
Wiebe van der Veen | alfa
Move over, lasers: Scientists can now create holograms from neutrons, too
21.10.2016 | National Institute of Standards and Technology (NIST)
Finding the lightest superdeformed triaxial atomic nucleus
20.10.2016 | The Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
24.10.2016 | Power and Electrical Engineering
24.10.2016 | Life Sciences
24.10.2016 | Life Sciences