Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Physical environment influences stem cell development

07.09.2010
Say Hebrew University, other researchers

A researcher at the Hebrew University of Jerusalem, together with Israeli and foreign collaborators, has revealed how physical qualities -- and not only chemical ones – may have an influence in determining how adult stem cells from the bone marrow develop into differentiated ones. This represents an important step in understanding the mechanisms that direct and regulate the specialization of stem cells from their undefined state.

Scientists around the world are involved in studying, describing and even manipulating the development of stem cells on their path into becoming specialized cells, such as heart, muscle, brain or any other tissue. This research has tremendous implications for the future utilization of stem cells as a new tool of medical treatment.

In an article published in Nature Physics, Dr. Assaf Zemel of the Institute of Dental Sciences at the Hebrew University and his fellow researchers, Prof. Samuel Safran from the Weizmann Institute of Science, Dr. Florian Rehfeldt from Gottingen University in Germany, and Dr. Andre Brown and Prof. Dennis Discher from the University of Pennsylvania, tell how they have developed a theoretical model and carried out experiments on stem cells to propose a mechanism for the recently discovered sensitivity of stem cell differentiation to the rigidity of their surroundings.

They described the physical changes that take place in stem cells that are layered on supporting foundations of differing rigidities. They showed that on a supporting matrix whose rigidity mimics that of muscle tissue, the cells become elongated and filled with aligned muscle-like fibers. The authors explain how this situation is fundamentally different from the case where the supporting substance is made either softer (to mimic brain tissue) or harder (to mimic bone tissue), in which case the cells adopt more symmetric structures and differentiate into brain and bone cells, respectively.

These findings shed new light on our understanding of the mechanisms that govern the differentiation of stem cells and may have important implications for the design of artificial tissues and the development of novel therapeutic strategies, says Dr. Zemel.

Jerry Barach | EurekAlert!
Further information:
http://www.huji.ac.il

More articles from Physics and Astronomy:

nachricht From rocks in Colorado, evidence of a 'chaotic solar system'
23.02.2017 | University of Wisconsin-Madison

nachricht Prediction: More gas-giants will be found orbiting Sun-like stars
22.02.2017 | Carnegie Institution for Science

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>