Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Making the Most of Your CT-Scan

30.01.2012
New computer modelling techniques for biomaterials enhance the possibilities of CT-data exploitation.

X-ray photography has been used for decades for medical purposes. Now, scientists have found new ways of obtaining precise and comprehensive data from x-ray computer tomography.

In the project BIO-CT-EXPLOIT, an international team of mathematicians, physicists, and engineers figured out new ways to extract valuable information from the data obtained in CT scans. The research project has led to new computer codes for medical applications. In future, they will be used for bone implants, surgery, and tissue engineering.

“If we want to make the most of our x-ray data, we need to have an excellent understanding of the microstructure we are looking at”, says project coordinator Professor Christian Hellmich from the Vienna University of Technology. “We created detailed, voxel-specific computer models of biological tissue. That way, we can gain information from the CT-scans which has not been accessible up until now.” The research team has pioneered concepts for the extraction of chemical information from CT-scans. Using micro-mechanical computer modelling, this information can be converted into a 3D-map of specific material properties. “It is an unparalleled, highly reliable simulation tool for structural design purposes”, Christian Hellmich says. It should not be difficult to use the newly developed computer codes for real-life applications: “Our prototype tools are fully compatible and pre-tailored for commercial simulation packages and the software that comes with commercial CT-devices”, says Hellmich.

Cooperation of Industry and Academic Research
In the BIO-CT-EXPLOIT-project, academic research and private companies collaborated very closely. Four private enterprises (Simpleware Ltd, InMatrixs, CADFEM GmbH, Skyscan NV.) and four academic partners (Vienna University of Technology, Universita Politecnica delle Marche, Politechnika Warszawska, Hochschule für Angewandte Wissenschaften Hamburg) joined forces to create computer codes, which are supposed to lead to commercially available software tools in the future. The consortium was coordinated by the Institute of Materials and Structures at the Vienna University of Technology. The project started on December 1, 2009 – funded by the European Union through the 7th Framework Programme within the programme “Research for the benefit of small and medium-sized enterprises (SMEs)”. Now, the funding period is over and the program is completed. “In only two years, we have accomplished our goals – the collaboration was very successful”, says coordinator Christian Hellmich.

Software Tool for Dentists
CADFEM, one of the private research partners, offers a complete portfolio of leading software tools for numerical simulations (particularly Finite Element analyses and Computer Aided Design and their interfaces). In the context of the joint research project, CADFEM has developed a software tool which allows a dentist to perform patient-specific simulations of a dental implant. With this tool, a dentist can calculate the stress pattern around the implant in the mandible for getting information on potential mechanical overloading of the bone. The results of the finite-element simulation significantly depend on a realistic characterization of the mechanical properties of the bone tissue. Previously, CADFEM modeled the mechanical properties of the bone tissue in a simplified manner and did not account for all effects (e.g. anisotropy, microstructure, correlation between gray values and stiffness) of the real bone.

Now, CADFEM can perform much more realistic simulations of patient-specific models. The technology provided by the academic research partners to CADFEM can directly be implement it into their existing software tool. The new technology developed within the BIO-CT-EXPLOIT project will have a huge impact on CADFEM’s further developments in the field of biomechanics, and helps them to better capture the behavior of bone tissues and tissue engineering scaffolds

3D modelling and image evaluation
SIMPLEWARE offers world-leading software and services for the conversion of 3D image data into high-quality CAD, Rapid Prototype, CFD, and Finite Element models. SIMPLEWARE customers range from international blue chip corporations to research institutes and universities world-wide. The determination of realistic elasticity properties from CT-data based micromechanics, as provided in an unprecedented fashion through the BIO-CT-EXPLOIT project, will significantly extend SIMPLEWARE’s portfolio in realistic simulation tools for complex problems related to bio-structures - and beyond.

SkyScan microtomography is available in a range of easy-to-use desktop instruments, which generate 3D images of the enduser’s samples’ morphology and internal microstructure, with resolution down to the sub-micrometer level. Software for visualization and analysis in 3D is included with all SkyScan systems. BIO-CT-EXPLOIT paved the way ot extending the software portfolio towards unique, novel features, such as image improvement through artefact removal, bone chemical composition, and mechanical property maps.

Skeletal Tissue Engineering

INMATRIXS Ltd was founded as an academic spin-off company by the Russian Academy of Science (RAS), Institute for Physical Chemistry of Ceramics. InMatrixs is a biomedical device and skeletal tissue engineering company to manufacture medical products based on calcium phosphate. The Company’s goal is to provide integrated and cost-effective healthcare solutions based on advanced tissue engineering concepts for the regeneration of damaged skeletal tissues, with particular emphasis on bone. BIO-CT-EXPLOIT has helped to unravel structure-property relations in INMATRIXS ceramics, and provided numerical tools to show the beneficial properties of these biomaterials. As such computer-aided quality assessment is expected to reach significant impotance in the future, BIO-CT-EXPLOIT has put INMATRIXS in a priviledged market position.

The SMEs and RTDs plan future collaboration, both with regards to commercialization of the produced tools, and for identification of exciting new research avenues.

Links:
http://bio-ct-exploit.imws.tuwien.ac.at
www.cadfem.de
www.simpleware.com
www.skyscan.be

Contact:
christian.hellmich@tuwien .ac.at (Christian Hellmich, TU Wien)
cmueller@cadfem.de (Christoph Müller, CADFEM)
p.young@simpleware.com (Philippe Young, SIMPLEWARE)
evi.bongaers@skyscan.be (Evi Bongaers, SKYSCAN)
vskomlev@gmail.com (Vladimir Komlev, INMATRIXS)

Dr. Florian Aigner | Technische Universität Wien
Further information:
http://www.tuwien.ac.at

More articles from Physics and Astronomy:

nachricht Quantum optical sensor for the first time tested in space – with a laser system from Berlin
23.01.2017 | Ferdinand-Braun-Institut Leibniz-Institut für Höchstfrequenztechnik

nachricht SF State astronomer searches for signs of life on Wolf 1061 exoplanet
20.01.2017 | San Francisco State University

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

Quantum optical sensor for the first time tested in space – with a laser system from Berlin

23.01.2017 | Physics and Astronomy

The interactome of infected neural cells reveals new therapeutic targets for Zika

23.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>