Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New calculations solve an old problem with DNA

21.12.2012
In a recent publication, researchers achieved new accuracy in the ability to measure energy differences between states of molecules, thus predicting which states will be observed: The normal (B-form) DNA will switch to left-handed (Z-form) DNA when it is physically twisted, or when a lot of salt is added to the solution.

The normal (B-form) DNA will switch to left-handed (Z-form) DNA when it is physically twisted, or when a lot of salt is added to the solution. Researchers at the University of Luxembourg were able to accurately calculate for the first time the amount of salt which is required to do this.
Josh Berryman

Researchers at the University of Luxembourg were able to accurately calculate for the first time the amount of salt which is required to do this. Z-DNA in the cell leads to loss of function and cancer.

It has been known since the seventies that excessive salt causes DNA to reverse its twist, from a right-handed spiral to a left-handed one. DNA in the Z form is treated by our natural repair enzymes as damaged, and is therefore usually deleted from the cell. Deletion of genetic material can lead to cancer or to other problems, so the B-Z transition is no mere curiosity. However such is the complexity of the DNA molecule that a theoretical explanation which correctly predicts the amount of salt to do this has never before been found.

... more about:
»B-form »DNA »DNA molecule »Z-form »energy differences

Dr. Josh Berryman and Professor Tanja Schilling of the University of Luxembourg have now been able to find a method of calculation which predicts this transition with unprecedented accuracy. With this success in describing the most enigmatic of molecules, the team is optimistic that they will be able to perform similar mathematical analyses for a variety of other substances.

"It will enable us to predict material properties such as melting temperatures or elasticity. And this will be done with high accuracy using our new technique. Hence, we can now design new materials and biomaterials on the computer more effectively than before," said Prof. Schilling.

Prof Schilling and Dr Berryman are physicists at the University’s Physics and Material Sciences Research Unit, which comprises a team of 50 researchers.

The paper entitled “Free Energies by Thermodynamic Integration Relative to an Exact Solution, Used to Find the Handedness-Switching Salt Concentration for DNA” was published in the Journal of Chemical Theory and Computation.

Britta Schlüter | idw
Further information:
http://www.uni.lu
http://pubs.acs.org/doi/abs/10.1021/ct3005968

Further reports about: B-form DNA DNA molecule Z-form energy differences

More articles from Physics and Astronomy:

nachricht Cosmic rays threaten future deep-space astronaut missions
22.10.2014 | University of New Hampshire

nachricht New window on the early Universe
22.10.2014 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Comparing Apples and Oranges? A Colloquium on International Comparative Urban Research

22.10.2014 | Event News

Battery Conference April 2015 in Aachen

16.10.2014 | Event News

Experts discuss new developments in the field of stem cell research and cell therapy

10.10.2014 | Event News

 
Latest News

Earliest modern human sequenced

22.10.2014 | Life Sciences

Continuous slab caster from Siemens receives FAC from Maanshan

22.10.2014 | Press release

'Shrinking goats' another indicator that climate change affects animal size

22.10.2014 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>