Fumes produced by welding contain manganese, an element that scientists have linked to neurological problems including Parkinson’s disease-like symptoms.
“In the United States alone, there are more than 1 million workers who perform welding as a part of their jobs,” says Brad Racette, MD, professor of neurology at Washington University School of Medicine. “If further investigation of this potential link between neurotoxic effects and these fumes proves it is valid, it would have a substantial public-health impact for the U.S. workforce and the economy.”
The study appears online April 6, 2011, in Neurology, the medical journal of the American Academy of Neurology.
The study involved 20 welders with no symptoms of Parkinson’s disease, 20 people with Parkinson’s disease who were not welders and 20 people who were not welders and did not have Parkinson’s. The welders were recruited from two shipyards and one metal fabrication company, and each had an average of 30,000 hours of lifetime welding exposure.
All participants were given brain PET and MRI scans and motor skills tests. A neurologist who specializes in movement disorders also examined all participants. The welders' average blood manganese levels were found to be two times the upper limits of normal blood manganese levels established in prior studies of general populations.
In one area of the brain, PET scans indicated that welders had an average 11.7 percent reduction in a marker of the chemical dopamine compared to people who did not weld. Dopamine helps nerve cells communicate and is decreased in specific brain regions in people with Parkinson’s disease. The welders’ motor skills test scores also showed mild movement difficulties that were not as extensive as those found in the early Parkinson’s disease patients.
Racette and his colleagues plan a larger follow-up study to clarify the potential links between welding and brain damage.
Criswell SR, Perlmutter JS, Videen TO, Moerlein SM, Flores HP, Birke AM, Racette BA. Reduced uptake of [18F]FDOPA PET in asymptomatic welders with occupational manganese exposure. Neurology, online April 6, 2011.
Funding from the Michael J. Fox Foundation, the National Institutes of Health, the Clinical Science Translational Award, the Neuroscience Blueprint Grant, the American Parkinson Disease Association (APDA) Advanced Research Center at Washington University, the Greater St. Louis Chapter of the APDA, the McDonnell Center for Higher Brain Function and the Barnes-Jewish Hospital Foundation supported this research.
Washington University School of Medicine’s 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children’s hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked fourth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children’s hospitals, the School of Medicine is linked to BJC HealthCare.
Michael C. Purdy | EurekAlert!
Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center
Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
19.06.2018 | Physics and Astronomy
19.06.2018 | Life Sciences
19.06.2018 | Physics and Astronomy