Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


VascuBone – a toolbox for customised vascularised bone implants


The EU project VascuBone was coordinated by the Fraunhofer Institute for In-terfacial Engineering and Biotechnology IGB and has reached the end of a 5-year funding period. In March 2015, the partners of this international research consortium met at the Würzburg Congress Centre to discuss the results of this successful project. The focus of the meeting was the newly developed “Vascu-Bone Toolbox” to apply advanced materials and tailor-made combinations to individualized bone defects.

The final meeting of the EU project VascuBone took place on March 30-31, 2015 in the Würzburg Congress Centre. The goal of this project was to improve bone implants depending on the defect, to minimize the risk of rejection while supporting the body’s own regenerative potential, and to promote new bone growth in different bone defects.

Cells on calcium phoshate: cell skeleton (red), cell connections (green), cell nuclei (blue).

The international consortium and invited guests met to evaluate the results of the original and innovative project goals. Nineteen partners from four European countries were involved during the whole funding period.

The greatest innovation in the past five years is the “VascuBoneToolbox,” which provides various components required for a customised bone implant that supports the body’s own self-healing capacity when it cannot meet its own regenerative needs following severe damage or injury.

The toolbox is comprised of three major components. The first component is a novel, diamond-coated ceramic granulate material with large pores. This material can be readily used as it is easily absorbed in defects, is biocompatible and facilitates the growth of bone cells.

The second major component is proteins acquired from the patient’s own blood to help promote bone tissue growth. The third component consists of cells from the patient’s blood or bone marrow that ensure that the implant is not rejected. Until now, surgeons have used either metal-based implants or tissue transplanted from a patient’s own pelvic bone.

“There are drawbacks to both options: metal remains a foreign material on the surface of which new bone cannot form. Tissue from a patient’s pelvis would be ideal but there is a limit to how much can be removed,” explained VascuBone project coordinator Heike Walles.

The biologist is professor of Tissue Engineering and Regenerative Medicine at the Würzburg University Hospital and Director of the Translational Centre “Regenerative Therapies for Oncology and Musculoskeletal Diseases” of the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB’s Würzburg branch.

The VascuBone researchers were already able to demonstrate in pre-clinical trials that the bone implants from the VascuBone “Toolbox” did not accelerate the growth of tumours. Various tests also showed that the implants were also ideal for regenerating bone that is weakened with age. Clinical trials are now underway that will allow the use of the implants in patients within a few years.

The project partners used the meeting to bring together the scientific findings regarding the implant construction and individual functionalisation with autologous cells and proteins. Quality control measures and imaging that have been implemented and the associated studies and tests were then presented. The relevance of tissue engineering was highlighted both from an industrial perspective and in terms of scientific research.

This research has received funding from the European Union’s Seventh Framework Programme under grant agreement no. 242175.

Weitere Informationen:

Dr. Claudia Vorbeck | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>